Degradation of NLRP3 by selective ROCK2 inhibitor alleviates acute lung injury.
Fuente:
PubMed
Saved in:
| Main Authors: | Zhan, Shuai, Zhang, Ningjing, Lou, Yijie, Ding, Xia, Chen, Zhe, Huang, Yun, Ding, Wanjing |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
European journal of pharmacology
2025
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
Design, Synthesis, and Evaluation of a Potent and Selective ROCK2 Inhibitor for Atopic Dermatitis Treatment.
by: Mao, Churu, et al.
Published: (2026)
by: Mao, Churu, et al.
Published: (2026)
Histone Deacetylase 6 Regulates α-Tubulin to Inhibit the Stimulator of Interferon Genes/NLR Family Pyrin Domain-Containing 3-Mediated Microglial Pyroptosis Induced by Herpes Simplex Virus Type 1 Infection.
by: Zeng, Qiongzhen, et al.
Published: (2026)
by: Zeng, Qiongzhen, et al.
Published: (2026)
BRD4-mediated transcriptional activation of PDLIM4 enhances p21 stability and chemosensitivity in lung adenocarcinoma independent of p53.
by: Wang, Qingwei, et al.
Published: (2026)
by: Wang, Qingwei, et al.
Published: (2026)
Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response.
by: Lu, Long-Feng, et al.
Published: (2026)
by: Lu, Long-Feng, et al.
Published: (2026)
Hippo-YAP pathway regulates antimicrobial immune response in obscure puffer Takifugu obscurus.
by: Wang, Ruixia, et al.
Published: (2025)
by: Wang, Ruixia, et al.
Published: (2025)
A Novel Exopolysaccharide, Highly Prevalent in Marine Spongiibacter, Triggers Pyroptosis to Exhibit Potent Anticancer Effects.
by: Liu, Ge, et al.
Published: (2025)
by: Liu, Ge, et al.
Published: (2025)
A nutrient-responsive AMPK/TBK1 circuit restricts adipocyte catabolism.
by: Wisessaowapak, Churaibhon, et al.
Published: (2026)
by: Wisessaowapak, Churaibhon, et al.
Published: (2026)
Cereblon upregulation overcomes thalidomide resistance in multiple myeloma through mitochondrial functional reprogramming.
by: Marquez, Jubert, et al.
Published: (2026)
by: Marquez, Jubert, et al.
Published: (2026)
Palmitoylation-mediated NLRP3 inflammasome activation in teleosts highlights evolutionary divergence in immune regulation.
by: Nie, Li, et al.
Published: (2025)
by: Nie, Li, et al.
Published: (2025)
Discovery of the First-in-Class Dual-Target ROCK/HDAC Inhibitor with Potent Antitumor Efficacy in Vivo That Trigger Antitumor Immunity.
by: Mao, Churu, et al.
Published: (2024)
by: Mao, Churu, et al.
Published: (2024)
RNF34 negatively regulates innate immunity via ubiquitin-mediated TAK1 degradation in miiuy croaker (Miichthysmiiuy).
by: Dong, Wenjing, et al.
Published: (2025)
by: Dong, Wenjing, et al.
Published: (2025)
Primary Cilia-Mediated Hedgehog Signaling Regulates Cell Fate During ER Stress-Induced Life or Death Decisions.
by: Xu, Jia, et al.
Published: (2025)
by: Xu, Jia, et al.
Published: (2025)
T3SS translocon induces pyroptosis by direct interaction with NLRC4/NAIP inflammasome.
by: Zhao, Yan, et al.
Published: (2025)
by: Zhao, Yan, et al.
Published: (2025)
Particulate matter 2.5 stimulates pyroptosis and necroptosis via the p38 MAPK/Akt/NF-κB signaling pathway in human corneal epithelial cells.
by: Kim, Da Hye, et al.
Published: (2025)
by: Kim, Da Hye, et al.
Published: (2025)
BIT1 as an Effector of EGFR-TKI-induced Apoptosis TLE1 Inhibition in Lung Adenocarcinoma Cells.
by: Dela Cruz, Ma Carmela, et al.
Published: (2026)
by: Dela Cruz, Ma Carmela, et al.
Published: (2026)
MYLIP attenuates hypoxia tolerance by inducing K27-linked polyubiquitination and subsequent proteasomal degradation of HIF-α.
by: Li, Jun, et al.
Published: (2025)
by: Li, Jun, et al.
Published: (2025)
Rapid, multiplex, one-pot CRISPR/Dx system for detecting cancer fusion genes.
by: Li, Jiaqi, et al.
Published: (2025)
by: Li, Jiaqi, et al.
Published: (2025)
BIK1 and ATL31/6 are essential for fucoidan hydrolysate-triggered stomatal closure in Arabidopsis.
by: Chen, Kexin, et al.
Published: (2025)
by: Chen, Kexin, et al.
Published: (2025)
Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors.
by: Du, Lin, et al.
Published: (2025)
by: Du, Lin, et al.
Published: (2025)
A mechanosensitive circuit of FAK, ROCK, and ERK controls biomineral growth and morphology in the sea urchin embryo.
by: Layous, Majed, et al.
Published: (2025)
by: Layous, Majed, et al.
Published: (2025)
Investigating the C2 Modulation of the Imidazo[1,2-a]pyrazine-Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition.
by: Tisseur, Lhana, et al.
Published: (2025)
by: Tisseur, Lhana, et al.
Published: (2025)
Phosphoethanolamine cytidylyltransferase 2 integrates DAG metabolism and TBK1 activation to regulate antiviral innate immunity.
by: Lai, Wencong, et al.
Published: (2026)
by: Lai, Wencong, et al.
Published: (2026)
Synthesis and biological activity of 1H-pyrrolo[3,2-g]isoquinolines as Haspin kinase inhibitors.
by: Malosse, Killian, et al.
Published: (2025)
by: Malosse, Killian, et al.
Published: (2025)
Epicoccin A Ameliorates PD-like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative Stress.
by: Ye, Haicheng, et al.
Published: (2025)
by: Ye, Haicheng, et al.
Published: (2025)
Neuroprotective mechanism of hydrogen sulfide in okadaic acid-induced alzheimer-like pathology.
by: Kamat, Pradip K, et al.
Published: (2026)
by: Kamat, Pradip K, et al.
Published: (2026)
Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships.
by: Bourg, Stéphane, et al.
Published: (2026)
by: Bourg, Stéphane, et al.
Published: (2026)
Autophagic degradation of MAVS-B by Carassius auratus herpesvirus (CaHV) ORF56 suppresses interferon response in polyploid gibel carp.
by: Zhou, Chu-Jing, et al.
Published: (2026)
by: Zhou, Chu-Jing, et al.
Published: (2026)
Elucidation of anti-human melanoma and anti-aging mechanisms of compounds from green seaweed Caulerpa racemosa.
by: Wicaksono, Danar, et al.
Published: (2024)
by: Wicaksono, Danar, et al.
Published: (2024)
Identification of Marine Compounds Inhibiting NF-κBInducing Kinase Through Molecular Docking and Molecular Dynamics Simulations.
by: Yasir, Muhammad, et al.
Published: (2024)
by: Yasir, Muhammad, et al.
Published: (2024)
Sun Exposure and Skin Cancer: A Narrative Review of Risk Factors, Prevention Behaviors, and Emerging Therapeutic Approaches
by: Silva, Luiz Felipe Rodrigues, et al.
Published: (2026)
by: Silva, Luiz Felipe Rodrigues, et al.
Published: (2026)
LECT2 promotes liver regeneration across developmental stages by activating the ADAM10-NOTCH signaling pathway.
by: Zhang, Hui, et al.
Published: (2025)
by: Zhang, Hui, et al.
Published: (2025)
The Evolution and Biological Activity of Metazoan Mixed Lineage Kinase Domain-Like Protein (MLKL).
by: Wang, Qingyue, et al.
Published: (2024)
by: Wang, Qingyue, et al.
Published: (2024)
Phosphorylation of peptides by a kinase domain in cyanobactin pathways.
by: Castelo-Branco, Raquel, et al.
Published: (2025)
by: Castelo-Branco, Raquel, et al.
Published: (2025)
Prkra dimer senses double-stranded RNAs to dictate global translation efficiency.
by: Lu, Tong, et al.
Published: (2025)
by: Lu, Tong, et al.
Published: (2025)
pVHL regulates protein stability of the TCF/LEF transcription factor family via ubiquitin-independent proteasomal degradation.
by: Wang, Caixia, et al.
Published: (2025)
by: Wang, Caixia, et al.
Published: (2025)
Starfish-Derived Extracts Enhance Mitophagy and Suppress Senescence-Associated Markers in Human Dermal Fibroblasts.
by: Lee, Hyun Jung, et al.
Published: (2025)
by: Lee, Hyun Jung, et al.
Published: (2025)
The CpxR-regulated periplasmic protease DegP coordinates the environmental stress adaptation, motility, and virulence in Edwardsiella piscicida.
by: Li, Hui, et al.
Published: (2025)
by: Li, Hui, et al.
Published: (2025)
MEK1/2 inhibition prevents DENV and ZIKV infection via disrupting the cytoskeletal vimentin cage required for viral replication.
by: Huang, Yuhan, et al.
Published: (2026)
by: Huang, Yuhan, et al.
Published: (2026)
Anti-Inflammatory Activity of Labdane and Norlabdane Diterpenoids from Leonurus sibiricus Related to Modulation of MAPKs Signaling Pathway.
by: Trang, Nguyen Minh, et al.
Published: (2025)
by: Trang, Nguyen Minh, et al.
Published: (2025)
ZIKV prM hijacks PIM1 kinase for phosphorylation to prevent ubiquitin-mediated degradation and facilitate viral replication.
by: Ren, Yingying, et al.
Published: (2024)
by: Ren, Yingying, et al.
Published: (2024)
Similar Items
-
Design, Synthesis, and Evaluation of a Potent and Selective ROCK2 Inhibitor for Atopic Dermatitis Treatment.
by: Mao, Churu, et al.
Published: (2026) -
Histone Deacetylase 6 Regulates α-Tubulin to Inhibit the Stimulator of Interferon Genes/NLR Family Pyrin Domain-Containing 3-Mediated Microglial Pyroptosis Induced by Herpes Simplex Virus Type 1 Infection.
by: Zeng, Qiongzhen, et al.
Published: (2026) -
BRD4-mediated transcriptional activation of PDLIM4 enhances p21 stability and chemosensitivity in lung adenocarcinoma independent of p53.
by: Wang, Qingwei, et al.
Published: (2026) -
Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response.
by: Lu, Long-Feng, et al.
Published: (2026) -
Hippo-YAP pathway regulates antimicrobial immune response in obscure puffer Takifugu obscurus.
by: Wang, Ruixia, et al.
Published: (2025)