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| Main Authors: | , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Archives of pharmacal research
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40750755/ |
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Table of Contents:
- 9H-carbazole derivatives from a Streptomyces species under potassium iodide stress and their anti-inflammatory properties. Yan, Pengcheng Liu, Yunlong Liu, Jibin Chen, Linmeng Li, Ning Zhu, Weiming Animals Streptomyces Zebrafish Carbazoles Potassium Iodide Molecular Structure Anti-Inflammatory Agents Copper Sulfate Inflammation Dose-Response Relationship, Drug Anti-Inflammatory Agents, Non-Steroidal NF-kappa B Structure-Activity Relationship By continuously activating silent gene cluster of the marine-derived Streptomyces strain OUCMDZ-5511 under high salt stress, three new iodinated 9H-carbazole derivatives (1-3) and a novel oxazole-fused chlorinated 9H-carbazole derivative (4), along with five previously reported analogues (5-9), were obtained from the cultures grown with 7.5% potassium iodide (KI). The structures of these previously undocumented compounds were elucidated as 4-iodo-3-methoxy-9H-carbazole (1), 4-iodo-3-methoxy-9H-carbazole-6-ol (2), 4-iodo-3-methoxy-9H-carbazole-8-ol (3), and 10-chloro-9-methoxy-6H-oxazolo[5,4-c]carbazole (4), using MS and NMR spectroscopic techniques. Notably, compound 3 demonstrated a more potent anti-inflammatory effect than the positive control in a CuSO-induced inflammation zebrafish model, likely by modulating the Myd88/NF-κB signaling pathway to exert its anti-inflammatory activity.