Anticancer activity of triterpene glycosides from the sea star Solaster pacificus.
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| Natura: | Artículo científico |
| Lingua: | en |
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Scientific reports
2025
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| author | Dyshlovoy, Sergey A Hauschild, Jessica Kriegs, Malte Hoffer, Konstantin Burenina, Olga Y Strewinsky, Nadja Malyarenko, Timofey V Kicha, Alla A Ivanchina, Natalia V Stonik, Valentin A Graefen, Markus Bokemeyer, Carsten von Amsberg, Gunhild |
| author_facet | Dyshlovoy, Sergey A Hauschild, Jessica Kriegs, Malte Hoffer, Konstantin Burenina, Olga Y Strewinsky, Nadja Malyarenko, Timofey V Kicha, Alla A Ivanchina, Natalia V Stonik, Valentin A Graefen, Markus Bokemeyer, Carsten von Amsberg, Gunhild Dyshlovoy, Sergey A Hauschild, Jessica Kriegs, Malte Hoffer, Konstantin Burenina, Olga Y Strewinsky, Nadja Malyarenko, Timofey V Kicha, Alla A Ivanchina, Natalia V Stonik, Valentin A Graefen, Markus Bokemeyer, Carsten von Amsberg, Gunhild |
| collection | PubMed - marine biology |
| contents | Anticancer activity of triterpene glycosides from the sea star Solaster pacificus. Dyshlovoy, Sergey A Hauschild, Jessica Kriegs, Malte Hoffer, Konstantin Burenina, Olga Y Strewinsky, Nadja Malyarenko, Timofey V Kicha, Alla A Ivanchina, Natalia V Stonik, Valentin A Graefen, Markus Bokemeyer, Carsten von Amsberg, Gunhild Glycosides Humans Triterpenes Starfish Animals Antineoplastic Agents Cell Line, Tumor Apoptosis Male Drug Resistance, Neoplasm Prostatic Neoplasms Marine triterpene glycosides are known to exhibit significant anticancer activity. We investigated pacificusoside C and cucumariosides C and C isolated from a sea star Solaster pacificus in prostate cancer models with varying drug resistance and in non-cancerous cells in vitro. Cucumarioside C showed selectivity comparable to cisplatin, whereas the other compounds were less selective. Cucumarioside C induced apoptosis and enhanced cytotoxic effects of cisplatin, carboplatin, docetaxel, and cabazitaxel, making it a potential candidate for combination therapy. All three glycosides were active in docetaxel-resistant cells and were neither inhibitors nor substrates of P-glycoprotein, indicating P-glycoprotein-independent activity. To explore the mechanism of anticancer activity of cucumarioside C, we performed functional kinome profiling of treated 22Rv1 cells, predicting activation of kinases involved in stress response and survival (IKKα, IKKβ, IKKε), necroptosis (MLKL), metabolism (GCN2, PDK1), cytoskeletal dynamics (RHOK), mitophagy (PINK1), apoptosis and cell cycle regulation (PITSLRE), and immune modulation (COT). Notably, only MAP kinases p38 and ERK1/2 were predicted to be specifically inhibited, that was further validated by Western blotting. These findings may potentially explain previously reported anticancer effects of cucumarioside C and related marine glycosides. To our knowledge, this is the first study to report triterpene glycosides' effects on the kinome of cancer cells. |
| format | Artículo científico |
| id | pubmed_40759693 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Scientific reports |
| record_format | pubmed |
| spellingShingle | Anticancer activity of triterpene glycosides from the sea star Solaster pacificus. Dyshlovoy, Sergey A Hauschild, Jessica Kriegs, Malte Hoffer, Konstantin Burenina, Olga Y Strewinsky, Nadja Malyarenko, Timofey V Kicha, Alla A Ivanchina, Natalia V Stonik, Valentin A Graefen, Markus Bokemeyer, Carsten von Amsberg, Gunhild Glycosides Humans Triterpenes Starfish Animals Antineoplastic Agents Cell Line, Tumor Apoptosis Male Drug Resistance, Neoplasm Prostatic Neoplasms Anticancer activity of triterpene glycosides from the sea star Solaster pacificus. Dyshlovoy, Sergey A Hauschild, Jessica Kriegs, Malte Hoffer, Konstantin Burenina, Olga Y Strewinsky, Nadja Malyarenko, Timofey V Kicha, Alla A Ivanchina, Natalia V Stonik, Valentin A Graefen, Markus Bokemeyer, Carsten von Amsberg, Gunhild Glycosides Humans Triterpenes Starfish Animals Antineoplastic Agents Cell Line, Tumor Apoptosis Male Drug Resistance, Neoplasm Prostatic Neoplasms Marine triterpene glycosides are known to exhibit significant anticancer activity. We investigated pacificusoside C and cucumariosides C and C isolated from a sea star Solaster pacificus in prostate cancer models with varying drug resistance and in non-cancerous cells in vitro. Cucumarioside C showed selectivity comparable to cisplatin, whereas the other compounds were less selective. Cucumarioside C induced apoptosis and enhanced cytotoxic effects of cisplatin, carboplatin, docetaxel, and cabazitaxel, making it a potential candidate for combination therapy. All three glycosides were active in docetaxel-resistant cells and were neither inhibitors nor substrates of P-glycoprotein, indicating P-glycoprotein-independent activity. To explore the mechanism of anticancer activity of cucumarioside C, we performed functional kinome profiling of treated 22Rv1 cells, predicting activation of kinases involved in stress response and survival (IKKα, IKKβ, IKKε), necroptosis (MLKL), metabolism (GCN2, PDK1), cytoskeletal dynamics (RHOK), mitophagy (PINK1), apoptosis and cell cycle regulation (PITSLRE), and immune modulation (COT). Notably, only MAP kinases p38 and ERK1/2 were predicted to be specifically inhibited, that was further validated by Western blotting. These findings may potentially explain previously reported anticancer effects of cucumarioside C and related marine glycosides. To our knowledge, this is the first study to report triterpene glycosides' effects on the kinome of cancer cells. |
| title | Anticancer activity of triterpene glycosides from the sea star Solaster pacificus. |
| topic | Glycosides Humans Triterpenes Starfish Animals Antineoplastic Agents Cell Line, Tumor Apoptosis Male Drug Resistance, Neoplasm Prostatic Neoplasms |
| url | https://pubmed.ncbi.nlm.nih.gov/40759693/ |