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| Format: | Artículo científico |
| Sprache: | en |
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Chemistry & biodiversity
2025
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/40789062/ |
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| author | Deng, Ruixuan Gu, Chao Wang, Jiqun Li, Xiaokang Xin, Xiujuan Yang, Yongcheng Li, Jian Xia, Conglong An, Faliang |
| author_facet | Deng, Ruixuan Gu, Chao Wang, Jiqun Li, Xiaokang Xin, Xiujuan Yang, Yongcheng Li, Jian Xia, Conglong An, Faliang Deng, Ruixuan Gu, Chao Wang, Jiqun Li, Xiaokang Xin, Xiujuan Yang, Yongcheng Li, Jian Xia, Conglong An, Faliang |
| collection | PubMed - marine biology |
| contents | Stellarin I: A Bioactive Cyclic Nonapeptide with Potent Anti-renal Fibrosis Activity from the Root of Stellaria yunnanensis Franch. Deng, Ruixuan Gu, Chao Wang, Jiqun Li, Xiaokang Xin, Xiujuan Yang, Yongcheng Li, Jian Xia, Conglong An, Faliang Plant Roots Animals Peptides, Cyclic Rats Fibrosis Cell Line Transforming Growth Factor beta1 Molecular Structure Plant Extracts Collagen Type I Kidney An undescribed cyclic nonapeptide (1) was isolated from the crude root extract of the medicinal plant Stellaria yunnanensis Franch. Comprehensive spectral analysis was performed utilizing high-resolution mass spectrometry, one- and two-dimensional nuclear magnetic resonance spectroscopy, and experimental and calculated circular dichroism spectroscopy to elucidate the structure of the cyclic nonapeptide (1), which was identified as cyclo-(Tyr-Ala-Thr-Leu-Thr-Ala-Phe-Ala-Thr). Anti-renal fibrosis activity evaluation of compounds 1-3 showed that they have potential for anti-renal fibrosis by reducing the expression of fibrotic protein collagen I in NRK-49F cells induced by TGF-β1. |
| format | Artículo científico |
| id | pubmed_40789062 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Chemistry & biodiversity |
| record_format | pubmed |
| spellingShingle | Stellarin I: A Bioactive Cyclic Nonapeptide with Potent Anti-renal Fibrosis Activity from the Root of Stellaria yunnanensis Franch. Deng, Ruixuan Gu, Chao Wang, Jiqun Li, Xiaokang Xin, Xiujuan Yang, Yongcheng Li, Jian Xia, Conglong An, Faliang Plant Roots Animals Peptides, Cyclic Rats Fibrosis Cell Line Transforming Growth Factor beta1 Molecular Structure Plant Extracts Collagen Type I Kidney Stellarin I: A Bioactive Cyclic Nonapeptide with Potent Anti-renal Fibrosis Activity from the Root of Stellaria yunnanensis Franch. Deng, Ruixuan Gu, Chao Wang, Jiqun Li, Xiaokang Xin, Xiujuan Yang, Yongcheng Li, Jian Xia, Conglong An, Faliang Plant Roots Animals Peptides, Cyclic Rats Fibrosis Cell Line Transforming Growth Factor beta1 Molecular Structure Plant Extracts Collagen Type I Kidney An undescribed cyclic nonapeptide (1) was isolated from the crude root extract of the medicinal plant Stellaria yunnanensis Franch. Comprehensive spectral analysis was performed utilizing high-resolution mass spectrometry, one- and two-dimensional nuclear magnetic resonance spectroscopy, and experimental and calculated circular dichroism spectroscopy to elucidate the structure of the cyclic nonapeptide (1), which was identified as cyclo-(Tyr-Ala-Thr-Leu-Thr-Ala-Phe-Ala-Thr). Anti-renal fibrosis activity evaluation of compounds 1-3 showed that they have potential for anti-renal fibrosis by reducing the expression of fibrotic protein collagen I in NRK-49F cells induced by TGF-β1. |
| title | Stellarin I: A Bioactive Cyclic Nonapeptide with Potent Anti-renal Fibrosis Activity from the Root of Stellaria yunnanensis Franch. |
| topic | Plant Roots Animals Peptides, Cyclic Rats Fibrosis Cell Line Transforming Growth Factor beta1 Molecular Structure Plant Extracts Collagen Type I Kidney |
| url | https://pubmed.ncbi.nlm.nih.gov/40789062/ |