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| Main Authors: | , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Nature
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40804517/ |
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| author | Piovani, Laura Gavriouchkina, Daria Parey, Elise Sarre, Luke A Peijnenburg, Katja T C A Martín-Durán, José María Rokhsar, Daniel S Satoh, Noriyuki de Mendoza, Alex Goto, Taichiro Marlétaz, Ferdinand |
| author_facet | Piovani, Laura Gavriouchkina, Daria Parey, Elise Sarre, Luke A Peijnenburg, Katja T C A Martín-Durán, José María Rokhsar, Daniel S Satoh, Noriyuki de Mendoza, Alex Goto, Taichiro Marlétaz, Ferdinand Piovani, Laura Gavriouchkina, Daria Parey, Elise Sarre, Luke A Peijnenburg, Katja T C A Martín-Durán, José María Rokhsar, Daniel S Satoh, Noriyuki de Mendoza, Alex Goto, Taichiro Marlétaz, Ferdinand |
| collection | PubMed - marine biology |
| contents | The genomic origin of the unique chaetognath body plan. Piovani, Laura Gavriouchkina, Daria Parey, Elise Sarre, Luke A Peijnenburg, Katja T C A Martín-Durán, José María Rokhsar, Daniel S Satoh, Noriyuki de Mendoza, Alex Goto, Taichiro Marlétaz, Ferdinand Animals DNA Methylation Evolution, Molecular Gene Duplication Genes, Homeobox Genome Genomics Phylogeny Aquatic Organisms The emergence of animal phyla, each with their unique body plan, was a rapid event in the history of animal life, yet its genomic underpinnings are still poorly understood. Here we investigate at the genomic, regulatory and cellular levels, the origin of one of the most distinctive animal phyla, the chaetognaths, whose organismal characteristics have historically complicated their phylogenetic placement. We show that these characteristics are reflected at the cell-type level by the expression of genes that originated in the chaetognath lineage, contributing to adaptation to planktonic life at the sensory and structural levels. Similarly to other members of gnathiferans (which also include rotifers and several other microscopic phyla), chaetognaths have undergone accelerated genomic evolution with gene loss and chromosomal fusions. Furthermore, they secondarily duplicated thousands of genes, without evidence for a whole-genome duplication, yielding, for instance, tandemly expanded Hox genes, as well as many phylum-specific genes. We also detected repeat-rich highly methylated neocentromeres and a simplified DNA methylation toolkit that is involved in mobile element repression rather than transcriptional control. Consistent with fossil evidence, our observations suggest that chaetognaths emerged after a phase of morphological simplification through a reinvention of organ systems paralleled by massive genomic reorganization, explaining the uniqueness of their body plan. |
| format | Artículo científico |
| id | pubmed_40804517 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Nature |
| record_format | pubmed |
| spellingShingle | The genomic origin of the unique chaetognath body plan. Piovani, Laura Gavriouchkina, Daria Parey, Elise Sarre, Luke A Peijnenburg, Katja T C A Martín-Durán, José María Rokhsar, Daniel S Satoh, Noriyuki de Mendoza, Alex Goto, Taichiro Marlétaz, Ferdinand Animals DNA Methylation Evolution, Molecular Gene Duplication Genes, Homeobox Genome Genomics Phylogeny Aquatic Organisms The genomic origin of the unique chaetognath body plan. Piovani, Laura Gavriouchkina, Daria Parey, Elise Sarre, Luke A Peijnenburg, Katja T C A Martín-Durán, José María Rokhsar, Daniel S Satoh, Noriyuki de Mendoza, Alex Goto, Taichiro Marlétaz, Ferdinand Animals DNA Methylation Evolution, Molecular Gene Duplication Genes, Homeobox Genome Genomics Phylogeny Aquatic Organisms The emergence of animal phyla, each with their unique body plan, was a rapid event in the history of animal life, yet its genomic underpinnings are still poorly understood. Here we investigate at the genomic, regulatory and cellular levels, the origin of one of the most distinctive animal phyla, the chaetognaths, whose organismal characteristics have historically complicated their phylogenetic placement. We show that these characteristics are reflected at the cell-type level by the expression of genes that originated in the chaetognath lineage, contributing to adaptation to planktonic life at the sensory and structural levels. Similarly to other members of gnathiferans (which also include rotifers and several other microscopic phyla), chaetognaths have undergone accelerated genomic evolution with gene loss and chromosomal fusions. Furthermore, they secondarily duplicated thousands of genes, without evidence for a whole-genome duplication, yielding, for instance, tandemly expanded Hox genes, as well as many phylum-specific genes. We also detected repeat-rich highly methylated neocentromeres and a simplified DNA methylation toolkit that is involved in mobile element repression rather than transcriptional control. Consistent with fossil evidence, our observations suggest that chaetognaths emerged after a phase of morphological simplification through a reinvention of organ systems paralleled by massive genomic reorganization, explaining the uniqueness of their body plan. |
| title | The genomic origin of the unique chaetognath body plan. |
| topic | Animals DNA Methylation Evolution, Molecular Gene Duplication Genes, Homeobox Genome Genomics Phylogeny Aquatic Organisms |
| url | https://pubmed.ncbi.nlm.nih.gov/40804517/ |