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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Molecules (Basel, Switzerland)
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40807346/ |
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| _version_ | 1868266165160116224 |
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| author | Pham, Giang Nam Florio Furno, Matteo Garcia-Sanchez, Juan A Munro, Patrick Abdoul-Latif, Fatouma Mohamed Boyer, Laurent Varese, Giovanna Cristina Mehiri, Mohamed |
| author_facet | Pham, Giang Nam Florio Furno, Matteo Garcia-Sanchez, Juan A Munro, Patrick Abdoul-Latif, Fatouma Mohamed Boyer, Laurent Varese, Giovanna Cristina Mehiri, Mohamed Pham, Giang Nam Florio Furno, Matteo Garcia-Sanchez, Juan A Munro, Patrick Abdoul-Latif, Fatouma Mohamed Boyer, Laurent Varese, Giovanna Cristina Mehiri, Mohamed |
| collection | PubMed - marine biology |
| contents | Amesilide, a New Bicyclic Polyketide from the Marine Fungus MUT6601. Pham, Giang Nam Florio Furno, Matteo Garcia-Sanchez, Juan A Munro, Patrick Abdoul-Latif, Fatouma Mohamed Boyer, Laurent Varese, Giovanna Cristina Mehiri, Mohamed Polyketides Anti-Bacterial Agents Staphylococcus aureus Humans Microbial Sensitivity Tests Molecular Structure Ascomycota Circular Dichroism Aquatic Organisms A new bicyclic polyketide, amesilide (), along with the previously reported metabolites, chamisides A (), B (), and E (), chaetoconvosins B () and C (), and chaetochromins A () and B (), were isolated from the marine fungus MUT6601. The structures of the compounds were determined by extensive spectrometric (HRMS) and spectroscopic (1D and 2D NMR) analyses, as well as specific rotation. Absolute configurations of the stereogenic centers of amesilide () were determined by a comparison of its experimental circular dichroism (CD) spectrum with its time-dependent density functional theory (TD-DFT) electronic circular dichroism (ECD) spectra. Among them, chaetochromins A () and B () showed strong antibacterial activity against S25 (MBC values of 12.50 µM and MIC values of 6.25 µM) and a moderate cytotoxicity against monocytes (THP-1) and peripheral blood cells (PBMC) (IC values of 33.65-40.01 µM). |
| format | Artículo científico |
| id | pubmed_40807346 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Molecules (Basel, Switzerland) |
| record_format | pubmed |
| spellingShingle | Amesilide, a New Bicyclic Polyketide from the Marine Fungus MUT6601. Pham, Giang Nam Florio Furno, Matteo Garcia-Sanchez, Juan A Munro, Patrick Abdoul-Latif, Fatouma Mohamed Boyer, Laurent Varese, Giovanna Cristina Mehiri, Mohamed Polyketides Anti-Bacterial Agents Staphylococcus aureus Humans Microbial Sensitivity Tests Molecular Structure Ascomycota Circular Dichroism Aquatic Organisms Amesilide, a New Bicyclic Polyketide from the Marine Fungus MUT6601. Pham, Giang Nam Florio Furno, Matteo Garcia-Sanchez, Juan A Munro, Patrick Abdoul-Latif, Fatouma Mohamed Boyer, Laurent Varese, Giovanna Cristina Mehiri, Mohamed Polyketides Anti-Bacterial Agents Staphylococcus aureus Humans Microbial Sensitivity Tests Molecular Structure Ascomycota Circular Dichroism Aquatic Organisms A new bicyclic polyketide, amesilide (), along with the previously reported metabolites, chamisides A (), B (), and E (), chaetoconvosins B () and C (), and chaetochromins A () and B (), were isolated from the marine fungus MUT6601. The structures of the compounds were determined by extensive spectrometric (HRMS) and spectroscopic (1D and 2D NMR) analyses, as well as specific rotation. Absolute configurations of the stereogenic centers of amesilide () were determined by a comparison of its experimental circular dichroism (CD) spectrum with its time-dependent density functional theory (TD-DFT) electronic circular dichroism (ECD) spectra. Among them, chaetochromins A () and B () showed strong antibacterial activity against S25 (MBC values of 12.50 µM and MIC values of 6.25 µM) and a moderate cytotoxicity against monocytes (THP-1) and peripheral blood cells (PBMC) (IC values of 33.65-40.01 µM). |
| title | Amesilide, a New Bicyclic Polyketide from the Marine Fungus MUT6601. |
| topic | Polyketides Anti-Bacterial Agents Staphylococcus aureus Humans Microbial Sensitivity Tests Molecular Structure Ascomycota Circular Dichroism Aquatic Organisms |
| url | https://pubmed.ncbi.nlm.nih.gov/40807346/ |