Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Carbohydrate research
2025
|
| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40816231/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Synthesis and characterization of selenourea-functionalized chitosan derivatives with enhanced antioxidant activity. Wang, Linqing Han, Xiangru Tian, Liguang Yuan, Yuting Zhang, Jingjing Mi, Yingqi Guo, Zhanyong Dong, Fang Chitosan Organoselenium Compounds Urea Antioxidants Mice Animals Picrates Cell Line Biphenyl Compounds Free Radical Scavengers Molecular Structure Selenium, an essential micronutrient for human health, has garnered significant interest owing to its multifaceted biological activities including antioxidant, anti-inflammatory, and antitumor properties. In this study, 14 novel chitosan derivatives bearing selenourea groups were synthesized by incorporating selenium into chitosan via nucleophilic substitution reactions. Structural confirmation was achieved through FTIR, H NMR, and ICP-MS analyses, confirming successful selenium incorporation. The derivatives demonstrated superior antioxidant performance, achieving >85 % DPPH radical scavenging at 0.8 mg/mL and exceptional superoxide anion radical inhibition (>95 % at 0.4 mg/mL), surpassing conventional urea-chitosan analogues (