Potential anti-ovarian cancer agent: Isoaaptamine interference epithelial-mesenchymal transition, induces intrinsic apoptosis, and suppresses angiogenesis.
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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
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European journal of pharmacology
2025
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| _version_ | 1868266165127610369 |
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| author | Su, I-Li Chen, Yen-Po Hsu, Ling-Chen Feng, Chien-Wei Tsui, Kuan-Hao Chen, Nan-Fu Sung, Ping-Jyun Kuo, Hsiao-Mei Wen, Zhi-Hong |
| author_facet | Su, I-Li Chen, Yen-Po Hsu, Ling-Chen Feng, Chien-Wei Tsui, Kuan-Hao Chen, Nan-Fu Sung, Ping-Jyun Kuo, Hsiao-Mei Wen, Zhi-Hong Su, I-Li Chen, Yen-Po Hsu, Ling-Chen Feng, Chien-Wei Tsui, Kuan-Hao Chen, Nan-Fu Sung, Ping-Jyun Kuo, Hsiao-Mei Wen, Zhi-Hong |
| collection | PubMed - marine biology |
| contents | Potential anti-ovarian cancer agent: Isoaaptamine interference epithelial-mesenchymal transition, induces intrinsic apoptosis, and suppresses angiogenesis. Su, I-Li Chen, Yen-Po Hsu, Ling-Chen Feng, Chien-Wei Tsui, Kuan-Hao Chen, Nan-Fu Sung, Ping-Jyun Kuo, Hsiao-Mei Wen, Zhi-Hong Epithelial-Mesenchymal Transition Humans Female Apoptosis Ovarian Neoplasms Neovascularization, Pathologic Cell Line, Tumor Antineoplastic Agents Reactive Oxygen Species Animals Human Umbilical Vein Endothelial Cells Membrane Potential, Mitochondrial Rats Cell Movement Angiogenesis Ovarian cancer (OC) often metastasizes to the peritoneal cavity, causing late-stage diagnosis with high mortality. Aaptamine and isoaaptamine, sponge-derived isomeric alkaloids, were investigated for the anti-tumor potential of isoaaptamine in OC cells. Isoaaptamine outperforms aaptamine, significantly reducing the viability of PA-1 and SKOV-3 cells with half maximal inhibitory concentration (IC) values of ∼5 μM and 15 μM, respectively. It induced apoptosis, increasing apoptotic cells by ∼3.5-fold (p |
| format | Artículo científico |
| id | pubmed_40816529 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | European journal of pharmacology |
| record_format | pubmed |
| spellingShingle | Potential anti-ovarian cancer agent: Isoaaptamine interference epithelial-mesenchymal transition, induces intrinsic apoptosis, and suppresses angiogenesis. Su, I-Li Chen, Yen-Po Hsu, Ling-Chen Feng, Chien-Wei Tsui, Kuan-Hao Chen, Nan-Fu Sung, Ping-Jyun Kuo, Hsiao-Mei Wen, Zhi-Hong Epithelial-Mesenchymal Transition Humans Female Apoptosis Ovarian Neoplasms Neovascularization, Pathologic Cell Line, Tumor Antineoplastic Agents Reactive Oxygen Species Animals Human Umbilical Vein Endothelial Cells Membrane Potential, Mitochondrial Rats Cell Movement Angiogenesis Potential anti-ovarian cancer agent: Isoaaptamine interference epithelial-mesenchymal transition, induces intrinsic apoptosis, and suppresses angiogenesis. Su, I-Li Chen, Yen-Po Hsu, Ling-Chen Feng, Chien-Wei Tsui, Kuan-Hao Chen, Nan-Fu Sung, Ping-Jyun Kuo, Hsiao-Mei Wen, Zhi-Hong Epithelial-Mesenchymal Transition Humans Female Apoptosis Ovarian Neoplasms Neovascularization, Pathologic Cell Line, Tumor Antineoplastic Agents Reactive Oxygen Species Animals Human Umbilical Vein Endothelial Cells Membrane Potential, Mitochondrial Rats Cell Movement Angiogenesis Ovarian cancer (OC) often metastasizes to the peritoneal cavity, causing late-stage diagnosis with high mortality. Aaptamine and isoaaptamine, sponge-derived isomeric alkaloids, were investigated for the anti-tumor potential of isoaaptamine in OC cells. Isoaaptamine outperforms aaptamine, significantly reducing the viability of PA-1 and SKOV-3 cells with half maximal inhibitory concentration (IC) values of ∼5 μM and 15 μM, respectively. It induced apoptosis, increasing apoptotic cells by ∼3.5-fold (p |
| title | Potential anti-ovarian cancer agent: Isoaaptamine interference epithelial-mesenchymal transition, induces intrinsic apoptosis, and suppresses angiogenesis. |
| topic | Epithelial-Mesenchymal Transition Humans Female Apoptosis Ovarian Neoplasms Neovascularization, Pathologic Cell Line, Tumor Antineoplastic Agents Reactive Oxygen Species Animals Human Umbilical Vein Endothelial Cells Membrane Potential, Mitochondrial Rats Cell Movement Angiogenesis |
| url | https://pubmed.ncbi.nlm.nih.gov/40816529/ |