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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine genomics
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40816770/ |
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Table of Contents:
- Complete genome sequence of Lysinibacillus sp. WB86, a potential antimicrobial lanthipeptides producer. Sun, Huai-Ying Xin, Ji-Xiang Li, Gen Zhou, Zhen-Yi Li, Xin Wang, Hong Yin, Qun-Jian Wei, Bin Genome, Bacterial Bacillaceae Whole Genome Sequencing Lysinibacillus sp. WB86 was isolated from a cold seep in the South China Sea, and its complete genome was sequenced using Oxford Nanopore Technologies (ONT). The genome consists of a single circular chromosome spanning 4,537,071 bp, with a G + C content of 37 %. FastANI analysis revealed a 99.38 % average nucleotide identity (ANI) with Lysinibacillus sphaericus A1, confirming its classification as a strain of L. sphaericus. Genome annotation identified 4397 protein-coding genes, along with 111 tRNAs and 34 rRNAs. Functional categorization using the COG database assigned 84.6 % of the protein-coding genes to specific roles, with the majority involved in transcription, amino acid transport and metabolism, translation and ribosomal biogenesis, and replication, recombination, and repair. Additionally, antiSMASH-based analysis uncovered eight biosynthetic gene clusters (BGCs), only one of which exhibited high similarity (>50 %) to known BGCs. This cluster was predicted to encode novel antimicrobial lanthipeptides, suggesting potential biotechnological applications.