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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Analytical chemistry
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40833281/ |
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| _version_ | 1868266162738954241 |
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| author | Negrín-Santamaría, Isaac Trujillo-Rodríguez, María J Moyano, Encarnación Ayala, Juan H Zuloaga, Olatz Pasán, Jorge Pino, Verónica Ayala-Cabrera, Juan F |
| author_facet | Negrín-Santamaría, Isaac Trujillo-Rodríguez, María J Moyano, Encarnación Ayala, Juan H Zuloaga, Olatz Pasán, Jorge Pino, Verónica Ayala-Cabrera, Juan F Negrín-Santamaría, Isaac Trujillo-Rodríguez, María J Moyano, Encarnación Ayala, Juan H Zuloaga, Olatz Pasán, Jorge Pino, Verónica Ayala-Cabrera, Juan F |
| collection | PubMed - marine biology |
| contents | Exploring Metal-Organic Framework-Coated Blades for Direct and High-Throughput Screening Analysis of Complex Biological Matrices. Negrín-Santamaría, Isaac Trujillo-Rodríguez, María J Moyano, Encarnación Ayala, Juan H Zuloaga, Olatz Pasán, Jorge Pino, Verónica Ayala-Cabrera, Juan F Metal-Organic Frameworks Humans High-Throughput Screening Assays Mass Spectrometry Xenobiotics Ambient ionization mass spectrometry (AIMS) techniques have become an emerging approach over the last years due to their simplicity, permitting high-throughput sample analysis by directly coupling with mass spectrometry while ensuring short analysis times. Among AIMS techniques, coated-blade spray (CBS) has stood out, as it ensures a significant enhancement of overall sensitivity, undoubtedly useful for human biofluid analysis. In parallel, the incorporation of advanced smart materials, such as metal-organic frameworks (MOFs), into analytical devices is increasing due to their outstanding ability to efficiently trap target analytes, such as industrial chemicals with diverse functionalities and polarities. This study integrates neat MOFs in CBS devices, without the need for any composite or additional materials, through a simple and mild strategy and shows their use in the determination of xenobiotics present in human urine samples. Moreover, a suspect screening workflow by high-resolution mass spectrometry (HRMS) has been developed for the first time to extend the chemical coverage of AIMS techniques. This simultaneous approach ensures a proper analytical quality performance, achieving limits of quantification (LOQs) down to 0.1 ng·mL despite requiring only 8 min for the entire procedure. |
| format | Artículo científico |
| id | pubmed_40833281 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Analytical chemistry |
| record_format | pubmed |
| spellingShingle | Exploring Metal-Organic Framework-Coated Blades for Direct and High-Throughput Screening Analysis of Complex Biological Matrices. Negrín-Santamaría, Isaac Trujillo-Rodríguez, María J Moyano, Encarnación Ayala, Juan H Zuloaga, Olatz Pasán, Jorge Pino, Verónica Ayala-Cabrera, Juan F Metal-Organic Frameworks Humans High-Throughput Screening Assays Mass Spectrometry Xenobiotics Exploring Metal-Organic Framework-Coated Blades for Direct and High-Throughput Screening Analysis of Complex Biological Matrices. Negrín-Santamaría, Isaac Trujillo-Rodríguez, María J Moyano, Encarnación Ayala, Juan H Zuloaga, Olatz Pasán, Jorge Pino, Verónica Ayala-Cabrera, Juan F Metal-Organic Frameworks Humans High-Throughput Screening Assays Mass Spectrometry Xenobiotics Ambient ionization mass spectrometry (AIMS) techniques have become an emerging approach over the last years due to their simplicity, permitting high-throughput sample analysis by directly coupling with mass spectrometry while ensuring short analysis times. Among AIMS techniques, coated-blade spray (CBS) has stood out, as it ensures a significant enhancement of overall sensitivity, undoubtedly useful for human biofluid analysis. In parallel, the incorporation of advanced smart materials, such as metal-organic frameworks (MOFs), into analytical devices is increasing due to their outstanding ability to efficiently trap target analytes, such as industrial chemicals with diverse functionalities and polarities. This study integrates neat MOFs in CBS devices, without the need for any composite or additional materials, through a simple and mild strategy and shows their use in the determination of xenobiotics present in human urine samples. Moreover, a suspect screening workflow by high-resolution mass spectrometry (HRMS) has been developed for the first time to extend the chemical coverage of AIMS techniques. This simultaneous approach ensures a proper analytical quality performance, achieving limits of quantification (LOQs) down to 0.1 ng·mL despite requiring only 8 min for the entire procedure. |
| title | Exploring Metal-Organic Framework-Coated Blades for Direct and High-Throughput Screening Analysis of Complex Biological Matrices. |
| topic | Metal-Organic Frameworks Humans High-Throughput Screening Assays Mass Spectrometry Xenobiotics |
| url | https://pubmed.ncbi.nlm.nih.gov/40833281/ |