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| Auteurs principaux: | , , , |
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| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Trends in endocrinology and metabolism: TEM
2025
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| Sujets: | |
| Accès en ligne: | https://pubmed.ncbi.nlm.nih.gov/40835484/ |
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| _version_ | 1868266162734759937 |
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| author | Jia, Jianxin Li, Zhehui Zhao, Liyuan Li, Mingyu |
| author_facet | Jia, Jianxin Li, Zhehui Zhao, Liyuan Li, Mingyu Jia, Jianxin Li, Zhehui Zhao, Liyuan Li, Mingyu |
| collection | PubMed - marine biology |
| contents | Glucagon receptor antagonism requires further mechanistic attention on α-cell physiology. Jia, Jianxin Li, Zhehui Zhao, Liyuan Li, Mingyu Glucagon-Secreting Cells Humans Receptors, Glucagon Animals Glucagon Glucagon receptor (GCGR) antagonism improves glycemic control; however, it also brings adverse effects through unclear underlying mechanisms. Here, we summarize emerging findings about the impact of GCGR blockade on α cells and discuss the challenges and potential of GCGR antagonism on clinical application. |
| format | Artículo científico |
| id | pubmed_40835484 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Trends in endocrinology and metabolism: TEM |
| record_format | pubmed |
| spellingShingle | Glucagon receptor antagonism requires further mechanistic attention on α-cell physiology. Jia, Jianxin Li, Zhehui Zhao, Liyuan Li, Mingyu Glucagon-Secreting Cells Humans Receptors, Glucagon Animals Glucagon Glucagon receptor antagonism requires further mechanistic attention on α-cell physiology. Jia, Jianxin Li, Zhehui Zhao, Liyuan Li, Mingyu Glucagon-Secreting Cells Humans Receptors, Glucagon Animals Glucagon Glucagon receptor (GCGR) antagonism improves glycemic control; however, it also brings adverse effects through unclear underlying mechanisms. Here, we summarize emerging findings about the impact of GCGR blockade on α cells and discuss the challenges and potential of GCGR antagonism on clinical application. |
| title | Glucagon receptor antagonism requires further mechanistic attention on α-cell physiology. |
| topic | Glucagon-Secreting Cells Humans Receptors, Glucagon Animals Glucagon |
| url | https://pubmed.ncbi.nlm.nih.gov/40835484/ |