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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of agricultural and food chemistry
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40836558/ |
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| _version_ | 1868266162732662784 |
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| author | Xiong, Lin-Qiang Li, Yu-Zhen Liang, Su-Ping Zhang, Chan Hu, Wen-Lin Yang, Qiong-Qiong Molnár, István Zhang, Bo-Bo |
| author_facet | Xiong, Lin-Qiang Li, Yu-Zhen Liang, Su-Ping Zhang, Chan Hu, Wen-Lin Yang, Qiong-Qiong Molnár, István Zhang, Bo-Bo Xiong, Lin-Qiang Li, Yu-Zhen Liang, Su-Ping Zhang, Chan Hu, Wen-Lin Yang, Qiong-Qiong Molnár, István Zhang, Bo-Bo |
| collection | PubMed - marine biology |
| contents | Efficient Production of Natural Yellow Azaphilone Pigments from Regulated by Microparticle-Triggered Stress. Xiong, Lin-Qiang Li, Yu-Zhen Liang, Su-Ping Zhang, Chan Hu, Wen-Lin Yang, Qiong-Qiong Molnár, István Zhang, Bo-Bo Monascus Pigments, Biological Benzopyrans Silicon Dioxide Reactive Oxygen Species Fungal Proteins Interaction with inert substances can profoundly affect the biosynthesis of metabolites in microorganisms. Here, we show that SiO microparticles cause changes in the cell morphology of . SiO also more than doubles the titer of yellow azaphilone pigments (YAzPs), reaching 788 U/mL. Transcriptomic and metabolomic analyses revealed that SiO microparticles modulated the expression of a large variety of genes and the production of key metabolites. In addition to upregulating the genes directly involved in YAzPs biosynthesis, the presence of SiO modulated the expression of key genes and the activities of key enzymes involved in calcium signaling and reactive oxygen species (ROS) response pathways. Together with SiO-caused membrane damage, these changes are in accord with elevated levels of Ca and ROS within the cells, as observed through specific reporters and validated by using inhibitors targeting these pathways. This research improves our understanding of the effects of inert substances on microbial metabolism. |
| format | Artículo científico |
| id | pubmed_40836558 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of agricultural and food chemistry |
| record_format | pubmed |
| spellingShingle | Efficient Production of Natural Yellow Azaphilone Pigments from Regulated by Microparticle-Triggered Stress. Xiong, Lin-Qiang Li, Yu-Zhen Liang, Su-Ping Zhang, Chan Hu, Wen-Lin Yang, Qiong-Qiong Molnár, István Zhang, Bo-Bo Monascus Pigments, Biological Benzopyrans Silicon Dioxide Reactive Oxygen Species Fungal Proteins Efficient Production of Natural Yellow Azaphilone Pigments from Regulated by Microparticle-Triggered Stress. Xiong, Lin-Qiang Li, Yu-Zhen Liang, Su-Ping Zhang, Chan Hu, Wen-Lin Yang, Qiong-Qiong Molnár, István Zhang, Bo-Bo Monascus Pigments, Biological Benzopyrans Silicon Dioxide Reactive Oxygen Species Fungal Proteins Interaction with inert substances can profoundly affect the biosynthesis of metabolites in microorganisms. Here, we show that SiO microparticles cause changes in the cell morphology of . SiO also more than doubles the titer of yellow azaphilone pigments (YAzPs), reaching 788 U/mL. Transcriptomic and metabolomic analyses revealed that SiO microparticles modulated the expression of a large variety of genes and the production of key metabolites. In addition to upregulating the genes directly involved in YAzPs biosynthesis, the presence of SiO modulated the expression of key genes and the activities of key enzymes involved in calcium signaling and reactive oxygen species (ROS) response pathways. Together with SiO-caused membrane damage, these changes are in accord with elevated levels of Ca and ROS within the cells, as observed through specific reporters and validated by using inhibitors targeting these pathways. This research improves our understanding of the effects of inert substances on microbial metabolism. |
| title | Efficient Production of Natural Yellow Azaphilone Pigments from Regulated by Microparticle-Triggered Stress. |
| topic | Monascus Pigments, Biological Benzopyrans Silicon Dioxide Reactive Oxygen Species Fungal Proteins |
| url | https://pubmed.ncbi.nlm.nih.gov/40836558/ |