Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
iScience
2025
|
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40837228/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266162730565634 |
|---|---|
| author | Liu, Tzu-Yen Yan, Jia-Jiun Guh, Ying-Jey Hayasaka, Oki Lin, Li-Yih Hwang, Pung-Pung Wu, Guan-Chung Chung, Ming-Tsung Tseng, Yung-Che |
| author_facet | Liu, Tzu-Yen Yan, Jia-Jiun Guh, Ying-Jey Hayasaka, Oki Lin, Li-Yih Hwang, Pung-Pung Wu, Guan-Chung Chung, Ming-Tsung Tseng, Yung-Che Liu, Tzu-Yen Yan, Jia-Jiun Guh, Ying-Jey Hayasaka, Oki Lin, Li-Yih Hwang, Pung-Pung Wu, Guan-Chung Chung, Ming-Tsung Tseng, Yung-Che |
| collection | PubMed - marine biology |
| contents | Epigenetic insights into physiological resilience: Multigenerational readouts of CO-induced seawater acidification effects on fish embryos. Liu, Tzu-Yen Yan, Jia-Jiun Guh, Ying-Jey Hayasaka, Oki Lin, Li-Yih Hwang, Pung-Pung Wu, Guan-Chung Chung, Ming-Tsung Tseng, Yung-Che Anthropogenic CO emissions are acidifying oceans, threatening marine organisms during early development. We investigated multigenerational effects of projected 2100 acidification (pH 7.6) on marine medaka () embryos across three generations using integrated phenotypic, physiological, transcriptomic, and epigenetic analyses. Prolonged acidification altered developmental trajectories, with F2 embryos showing size reductions. Metabolic responses were generation-specific: F0 embryos displayed decreased ammonium excretion, while F1 and F2 maintained stable profiles. Transcriptomic analysis revealed generational changes in neurotransmission, ion regulation, and epigenetic pathways. F2 embryos exhibited attenuated transcriptional perturbations and partial restoration of acid-base homeostasis, suggesting enhanced adaptability. Adaptive gene expression correlated with hypomethylation recovery of ion transport genes AE1a and NHE2 in F2 embryos. Increased hypomethylated AE1a promoter CpG sites in F1 and F2 generations aligned with elevated transcription, indicating epigenetically-driven enhancement. These results demonstrate epigenetic control's crucial role in multigenerational plasticity and adaptive responses to ocean acidification. |
| format | Artículo científico |
| id | pubmed_40837228 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | iScience |
| record_format | pubmed |
| spellingShingle | Epigenetic insights into physiological resilience: Multigenerational readouts of CO-induced seawater acidification effects on fish embryos. Liu, Tzu-Yen Yan, Jia-Jiun Guh, Ying-Jey Hayasaka, Oki Lin, Li-Yih Hwang, Pung-Pung Wu, Guan-Chung Chung, Ming-Tsung Tseng, Yung-Che Epigenetic insights into physiological resilience: Multigenerational readouts of CO-induced seawater acidification effects on fish embryos. Liu, Tzu-Yen Yan, Jia-Jiun Guh, Ying-Jey Hayasaka, Oki Lin, Li-Yih Hwang, Pung-Pung Wu, Guan-Chung Chung, Ming-Tsung Tseng, Yung-Che Anthropogenic CO emissions are acidifying oceans, threatening marine organisms during early development. We investigated multigenerational effects of projected 2100 acidification (pH 7.6) on marine medaka () embryos across three generations using integrated phenotypic, physiological, transcriptomic, and epigenetic analyses. Prolonged acidification altered developmental trajectories, with F2 embryos showing size reductions. Metabolic responses were generation-specific: F0 embryos displayed decreased ammonium excretion, while F1 and F2 maintained stable profiles. Transcriptomic analysis revealed generational changes in neurotransmission, ion regulation, and epigenetic pathways. F2 embryos exhibited attenuated transcriptional perturbations and partial restoration of acid-base homeostasis, suggesting enhanced adaptability. Adaptive gene expression correlated with hypomethylation recovery of ion transport genes AE1a and NHE2 in F2 embryos. Increased hypomethylated AE1a promoter CpG sites in F1 and F2 generations aligned with elevated transcription, indicating epigenetically-driven enhancement. These results demonstrate epigenetic control's crucial role in multigenerational plasticity and adaptive responses to ocean acidification. |
| title | Epigenetic insights into physiological resilience: Multigenerational readouts of CO-induced seawater acidification effects on fish embryos. |
| url | https://pubmed.ncbi.nlm.nih.gov/40837228/ |