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Autori principali:	Abdelhady, Mai E, Elmosalamy, Khaled H, Kattaia, Asmaa A A, Samak, Mai A
Natura:	Artículo científico
Lingua:	en
Pubblicazione:	Medical sciences (Basel, Switzerland) 2025
Soggetti:	Animals Spirulina Simvastatin Male Dyslipidemias Muscle, Skeletal Rats Diet, High-Fat Muscular Diseases Malondialdehyde Creatine Kinase
Accesso online:	https://pubmed.ncbi.nlm.nih.gov/40843759/
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author	Abdelhady, Mai E Elmosalamy, Khaled H Kattaia, Asmaa A A Samak, Mai A
author_facet	Abdelhady, Mai E Elmosalamy, Khaled H Kattaia, Asmaa A A Samak, Mai A Abdelhady, Mai E Elmosalamy, Khaled H Kattaia, Asmaa A A Samak, Mai A
collection	PubMed - marine biology
contents	Effect of Versus Simvastatin on the Skeletal Muscles of Experimentally Induced Dyslipidemia: A Multitarget Approach to Muscle Ultrastructural and Cytomolecular Modulation. Abdelhady, Mai E Elmosalamy, Khaled H Kattaia, Asmaa A A Samak, Mai A Animals Spirulina Simvastatin Male Dyslipidemias Muscle, Skeletal Rats Diet, High-Fat Muscular Diseases Malondialdehyde Creatine Kinase Dyslipidemia is a prevalent metabolic disorder closely linked to cardiovascular complications and muscular pathologies, often managed using statins such as simvastatin. However, statin-induced myopathy remains a significant treatment-limiting side effect, necessitating the exploration of safe, natural alternatives. , a phytochemical-rich marine-derived cyanobacterium, has emerged as a promising bioactive nutraceutical with potent antioxidant and anti-inflammatory properties. This study evaluated the comparative effects of and simvastatin in attenuating dyslipidemia-induced skeletal muscle injury in adult male albino rats. Forty animals were allocated to the control and high-fat diet (HFD) groups. After 4 weeks, the dyslipidemic rats were subdivided into untreated, simvastatin-treated, and -treated subgroups. Serum lipid profile, creatine kinase (CK), and malondialdehyde (MDA) levels were assessed. Histological, ultrastructural, and immunohistochemical analyses were conducted to assess muscle fiber integrity and expression of TGF-β1 and Bcl2. significantly improved lipid parameters, reduced CK and MDA levels, preserved muscle histoarchitecture, and downregulated fibrotic (↓TGF-β1) and apoptotic (↑Bcl2) responses compared to the dyslipidemic and simvastatin-treated groups. Our results proved that ameliorates the effects of statin-associated myopathy while exerting lipid-lowering, cytoprotective, and antifibrotic effects. These molecular and ultrastructural benefits position as a promising, natural alternative to statins for managing dyslipidemia and preventing statin-induced myopathy. Future translational and clinical studies are warranted to further validate its efficacy and safety, supporting its broader application in metabolic and muscle-related disorders.
format	Artículo científico
id	pubmed_40843759
institution	PubMed
language	en
publishDate	2025
publisher	Medical sciences (Basel, Switzerland)
record_format	pubmed
spellingShingle	Effect of Versus Simvastatin on the Skeletal Muscles of Experimentally Induced Dyslipidemia: A Multitarget Approach to Muscle Ultrastructural and Cytomolecular Modulation. Abdelhady, Mai E Elmosalamy, Khaled H Kattaia, Asmaa A A Samak, Mai A Animals Spirulina Simvastatin Male Dyslipidemias Muscle, Skeletal Rats Diet, High-Fat Muscular Diseases Malondialdehyde Creatine Kinase Effect of Versus Simvastatin on the Skeletal Muscles of Experimentally Induced Dyslipidemia: A Multitarget Approach to Muscle Ultrastructural and Cytomolecular Modulation. Abdelhady, Mai E Elmosalamy, Khaled H Kattaia, Asmaa A A Samak, Mai A Animals Spirulina Simvastatin Male Dyslipidemias Muscle, Skeletal Rats Diet, High-Fat Muscular Diseases Malondialdehyde Creatine Kinase Dyslipidemia is a prevalent metabolic disorder closely linked to cardiovascular complications and muscular pathologies, often managed using statins such as simvastatin. However, statin-induced myopathy remains a significant treatment-limiting side effect, necessitating the exploration of safe, natural alternatives. , a phytochemical-rich marine-derived cyanobacterium, has emerged as a promising bioactive nutraceutical with potent antioxidant and anti-inflammatory properties. This study evaluated the comparative effects of and simvastatin in attenuating dyslipidemia-induced skeletal muscle injury in adult male albino rats. Forty animals were allocated to the control and high-fat diet (HFD) groups. After 4 weeks, the dyslipidemic rats were subdivided into untreated, simvastatin-treated, and -treated subgroups. Serum lipid profile, creatine kinase (CK), and malondialdehyde (MDA) levels were assessed. Histological, ultrastructural, and immunohistochemical analyses were conducted to assess muscle fiber integrity and expression of TGF-β1 and Bcl2. significantly improved lipid parameters, reduced CK and MDA levels, preserved muscle histoarchitecture, and downregulated fibrotic (↓TGF-β1) and apoptotic (↑Bcl2) responses compared to the dyslipidemic and simvastatin-treated groups. Our results proved that ameliorates the effects of statin-associated myopathy while exerting lipid-lowering, cytoprotective, and antifibrotic effects. These molecular and ultrastructural benefits position as a promising, natural alternative to statins for managing dyslipidemia and preventing statin-induced myopathy. Future translational and clinical studies are warranted to further validate its efficacy and safety, supporting its broader application in metabolic and muscle-related disorders.
title	Effect of Versus Simvastatin on the Skeletal Muscles of Experimentally Induced Dyslipidemia: A Multitarget Approach to Muscle Ultrastructural and Cytomolecular Modulation.
topic	Animals Spirulina Simvastatin Male Dyslipidemias Muscle, Skeletal Rats Diet, High-Fat Muscular Diseases Malondialdehyde Creatine Kinase
url	https://pubmed.ncbi.nlm.nih.gov/40843759/

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