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| Main Authors: | , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
PLoS biology
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40857221/ |
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| _version_ | 1868266160101785601 |
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| author | Wang, Hao Cao, Lei Zhang, Huan Zhong, Zhaoshan Zhou, Li Lian, Chao Wang, Xiaocheng Chen, Hao Wang, Minxiao Zhang, Xin Li, Chaolun |
| author_facet | Wang, Hao Cao, Lei Zhang, Huan Zhong, Zhaoshan Zhou, Li Lian, Chao Wang, Xiaocheng Chen, Hao Wang, Minxiao Zhang, Xin Li, Chaolun Wang, Hao Cao, Lei Zhang, Huan Zhong, Zhaoshan Zhou, Li Lian, Chao Wang, Xiaocheng Chen, Hao Wang, Minxiao Zhang, Xin Li, Chaolun |
| collection | PubMed - marine biology |
| contents | A deep-sea hydrothermal vent worm detoxifies arsenic and sulfur by intracellular biomineralization of orpiment (As2S3). Wang, Hao Cao, Lei Zhang, Huan Zhong, Zhaoshan Zhou, Li Lian, Chao Wang, Xiaocheng Chen, Hao Wang, Minxiao Zhang, Xin Li, Chaolun Animals Hydrothermal Vents Biomineralization Arsenic Sulfur Polychaeta Hydrogen Sulfide Sulfides Epithelial Cells The alvinellid worm Paralvinella hessleri is the only animal that colonizes the hottest part of deep-sea hydrothermal vents in the west pacific. We found P. hessleri accumulates exceptionally high level of toxic element arsenic (>1% of wet weight) and tolerated elevated concentrations hydrogen sulphide. Using advanced microscopy, elementary analysis, and genomics and proteomics approaches, we identified a previously unrecognized arsenic-sulfide biomineralization process in P. hessleri. Our data suggest that arsenic accumulates within epithelial cell granules, where it likely reacts with sulphide diffused inward from the hydrothermal vent fluid, resulting in the intracellular formation of orpiment (As₂S₃) minerals. In this "fighting poison with poison" manner, the highly toxic arsenic and sulphide were simultaneously detoxified in the form of orpiment minerals within the intracellular granules of the single layer of epithelial cells. This process represents a remarkable adaptation to extreme chemical environments. Our study provides new insights into understanding animals' environment adaptation mechanisms and the diversity and plasticity of biomineralization. |
| format | Artículo científico |
| id | pubmed_40857221 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | PLoS biology |
| record_format | pubmed |
| spellingShingle | A deep-sea hydrothermal vent worm detoxifies arsenic and sulfur by intracellular biomineralization of orpiment (As2S3). Wang, Hao Cao, Lei Zhang, Huan Zhong, Zhaoshan Zhou, Li Lian, Chao Wang, Xiaocheng Chen, Hao Wang, Minxiao Zhang, Xin Li, Chaolun Animals Hydrothermal Vents Biomineralization Arsenic Sulfur Polychaeta Hydrogen Sulfide Sulfides Epithelial Cells A deep-sea hydrothermal vent worm detoxifies arsenic and sulfur by intracellular biomineralization of orpiment (As2S3). Wang, Hao Cao, Lei Zhang, Huan Zhong, Zhaoshan Zhou, Li Lian, Chao Wang, Xiaocheng Chen, Hao Wang, Minxiao Zhang, Xin Li, Chaolun Animals Hydrothermal Vents Biomineralization Arsenic Sulfur Polychaeta Hydrogen Sulfide Sulfides Epithelial Cells The alvinellid worm Paralvinella hessleri is the only animal that colonizes the hottest part of deep-sea hydrothermal vents in the west pacific. We found P. hessleri accumulates exceptionally high level of toxic element arsenic (>1% of wet weight) and tolerated elevated concentrations hydrogen sulphide. Using advanced microscopy, elementary analysis, and genomics and proteomics approaches, we identified a previously unrecognized arsenic-sulfide biomineralization process in P. hessleri. Our data suggest that arsenic accumulates within epithelial cell granules, where it likely reacts with sulphide diffused inward from the hydrothermal vent fluid, resulting in the intracellular formation of orpiment (As₂S₃) minerals. In this "fighting poison with poison" manner, the highly toxic arsenic and sulphide were simultaneously detoxified in the form of orpiment minerals within the intracellular granules of the single layer of epithelial cells. This process represents a remarkable adaptation to extreme chemical environments. Our study provides new insights into understanding animals' environment adaptation mechanisms and the diversity and plasticity of biomineralization. |
| title | A deep-sea hydrothermal vent worm detoxifies arsenic and sulfur by intracellular biomineralization of orpiment (As2S3). |
| topic | Animals Hydrothermal Vents Biomineralization Arsenic Sulfur Polychaeta Hydrogen Sulfide Sulfides Epithelial Cells |
| url | https://pubmed.ncbi.nlm.nih.gov/40857221/ |