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| Main Authors: | , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Pharmaceutics
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40871012/ |
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Table of Contents:
- Algal Metabolites as Novel Therapeutics Against Methicillin-Resistant (MRSA): A Review. Ibraheem, Ibraheem Borie M Alharbi, Reem Mohammed Abdel-Raouf, Neveen Al-Enazi, Nouf Mohammad Alsamhary, Khawla Ibrahim Ali, Hager Mohammed Methicillin-resistant (MRSA), a multidrug-resistant pathogen, poses a significant threat to global healthcare. This review evaluates the potential of marine algal metabolites as novel antibacterial agents against MRSA. We explore the clinical importance of , the emergence of MRSA as a "superbug", and its resistance mechanisms, including target modification, drug inactivation, efflux pumps, biofilm formation, and quorum sensing. The limitations of conventional antibiotics (e.g., β-lactams, vancomycin, macrolides) are discussed, alongside the promise of algal-derived compounds such as fatty acids, pigments, polysaccharides, terpenoids, and phenolic compounds. These metabolites exhibit potent anti-MRSA activity by disrupting cell division (via FtsZ inhibition), destabilizing membranes, and inhibiting protein synthesis and metabolic pathways, effectively countering multiple resistance mechanisms. Leveraging advances in algal biotechnology, this review highlights the untapped potential of marine algae to drive innovative, sustainable therapeutic strategies against antibiotic resistance.