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| Main Authors: | , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Biology
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40906372/ |
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| _version_ | 1868266157461471234 |
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| author | Zheng, Junyi Zhao, Hualong Wei, Lisha Jiang, Jinjun Xia, Wenlong |
| author_facet | Zheng, Junyi Zhao, Hualong Wei, Lisha Jiang, Jinjun Xia, Wenlong Zheng, Junyi Zhao, Hualong Wei, Lisha Jiang, Jinjun Xia, Wenlong |
| collection | PubMed - marine biology |
| contents | Tensins in Cancer: Integration of Their Domain Functions, Context-Dependent Regulation and Biomarker Potential. Zheng, Junyi Zhao, Hualong Wei, Lisha Jiang, Jinjun Xia, Wenlong Tensins (TNS1-4) are pivotal molecular scaffolds bridging the actin cytoskeleton to integrin-based adhesions, orchestrating signal transduction and governing cellular processes in cancer. Structurally, the N-terminal actin-binding domain (ABD) in TNS1-3 enables cytoskeletal regulation and interactions with regulators like the Rho GAP DLC1, while ABD-deficient TNS4 functions as a focal adhesion signal amplifier. Functionally, TNS1-3 exhibit context-dependent duality as tumor promoters or suppressors, dictated by tissue-specific microenvironments and signaling crosstalk. In contrast, TNS4 acts predominantly as an oncoprotein across carcinomas by stabilizing epidermal growth factor receptor (EGFR), driving epithelial-mesenchymal transition and invasion, and sustaining proliferation. Clinically, tensin dysregulation correlates with metastasis and poor prognosis: TNS2 serves as a diagnostic biomarker for gastrointestinal stromal tumors, aberrant TNS1/TNS3 expression predicts metastasis risk, and TNS4 is recurrently embedded in multi-gene prognostic signatures. This review synthesizes their structural basis, regulatory mechanisms, and clinical relevance, highlighting context-dependent switches and TNS4's therapeutic potential. |
| format | Artículo científico |
| id | pubmed_40906372 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Biology |
| record_format | pubmed |
| spellingShingle | Tensins in Cancer: Integration of Their Domain Functions, Context-Dependent Regulation and Biomarker Potential. Zheng, Junyi Zhao, Hualong Wei, Lisha Jiang, Jinjun Xia, Wenlong Tensins in Cancer: Integration of Their Domain Functions, Context-Dependent Regulation and Biomarker Potential. Zheng, Junyi Zhao, Hualong Wei, Lisha Jiang, Jinjun Xia, Wenlong Tensins (TNS1-4) are pivotal molecular scaffolds bridging the actin cytoskeleton to integrin-based adhesions, orchestrating signal transduction and governing cellular processes in cancer. Structurally, the N-terminal actin-binding domain (ABD) in TNS1-3 enables cytoskeletal regulation and interactions with regulators like the Rho GAP DLC1, while ABD-deficient TNS4 functions as a focal adhesion signal amplifier. Functionally, TNS1-3 exhibit context-dependent duality as tumor promoters or suppressors, dictated by tissue-specific microenvironments and signaling crosstalk. In contrast, TNS4 acts predominantly as an oncoprotein across carcinomas by stabilizing epidermal growth factor receptor (EGFR), driving epithelial-mesenchymal transition and invasion, and sustaining proliferation. Clinically, tensin dysregulation correlates with metastasis and poor prognosis: TNS2 serves as a diagnostic biomarker for gastrointestinal stromal tumors, aberrant TNS1/TNS3 expression predicts metastasis risk, and TNS4 is recurrently embedded in multi-gene prognostic signatures. This review synthesizes their structural basis, regulatory mechanisms, and clinical relevance, highlighting context-dependent switches and TNS4's therapeutic potential. |
| title | Tensins in Cancer: Integration of Their Domain Functions, Context-Dependent Regulation and Biomarker Potential. |
| url | https://pubmed.ncbi.nlm.nih.gov/40906372/ |