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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine biotechnology (New York, N.Y.)
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40908376/ |
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Table of Contents:
- Onnamides and a Novel Analogue, Onnamide G, as Potent Leishmanicidal Agents. Jomori, Takahiro Higa, Nanami Tyas, Trianda Ayuning Matsuura, Natsuki Ueda, Yudai Suetake, Ayumi Miyazaki, Shin Watanabe, Shuichi Arizono, Sei Hayashi, Yasuhiro Yasumoto, Ko Ise, Yuji Wakimoto, Toshiyuki Yasumoto-Hirose, Mina Tanaka, Junichi Mori-Yasumoto, Kanami Humans Animals Hep G2 Cells Antiprotozoal Agents Structure-Activity Relationship Leishmania major Amphotericin B Porifera Leishmaniasis is a neglected tropical disease posing significant global health challenges. Given the limited effective treatment options and associated constraints, many patients are unable to complete therapy. In this study, we report the remarkable leishmanicidal activity of onnamides derived from the marine sponge Theonella sp. against the promastigote form of Leishmania major (IC = 0.2-140 nM) and demonstrate their selectivity through cytotoxicity assessments on human hepatoma HepG2 cells. Structural-activity relationship (SAR) analyses were conducted using 6,7-dihydro-onnamide A and its analogs. Furthermore, we compared the action mechanisms of amphotericin B, the primary drug currently used for treatment, and the obtained onnamides. Based on biological evaluations and SAR studies, onnamides can be considered promising candidates for anti-leishmanial chemotherapy, warranting further investigation.