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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
RSC advances
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40917609/ |
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Table of Contents:
- Bioassay-guided isolation of terpenoids from the soft coral and assessment of their antidiabetic and cytotoxic activities. Luu, Phuong Vu Huynh, Quoc-Dung Tran Pham, Ngoc-Thac Le, Huong-Giang Chen, Lo-Yun Nguyen, Cuong-Quoc Ton-Nu, Huong Lien Lee, Mei-Hsien Chang, Yu-Chia Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung This study represents the first report on the secondary metabolites from the soft coral . Nine terpenoids (1-9) were isolated by antidiabetic-guided isolation, including a new xeniaphyllane-type diterpenoid (Sclerohumin O, 1) and a new norcaryophyllene-type sesquiterpenoid (Norsclerohumin P, 6). These compounds feature a distinctive 4/9-fused ring system, which was the first isolated in the genus. All compounds were subjected to evaluation for their antidiabetic and cytotoxic activities. Notably, compound 1 demonstrated substantial inhibitory activity against key metabolic enzymes implicated in diabetes, namely α-amylase, α-glucosidase, and lipase, with IC values of 100.3 ± 1.02, 170.0 ± 0.92, and 16.1 ± 2.15 μM, respectively. Moreover, compound 1 demonstrated potent cytotoxicity against pancreatic cancer cell lines, with IC values of 11.01 ± 1.43 μM (MIA PaCa-2), 19.06 ± 0.28 μM (Panc-1), and 17.86 ± 0.87 μM (KPC). Additionally, compounds 3 and 4 showed strong inhibitory activity against the MIA PaCa-2 cell line, with IC values of 2.52 ± 0.27 μM and 2.54 ± 0.38 μM, respectively. Enzyme kinetics, molecular docking, and molecular dynamics simulations were also performed to further elucidate the experimental findings. These results underscore the potential of marine-derived terpenoids as promising multifunctional bioactive agents with therapeutic applications in the management of diabetes, obesity, and pancreatic cancer.