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| Main Authors: | , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Bioorganic chemistry
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40934769/ |
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Table of Contents:
- Biogenic gold nanoparticles synthesized from Caulerpa sertularioides: A green approach for antioxidant, antibacterial and anticancer applications. Sivakumar, Vibitha Sri Palanisamy, Subramanian Rajasekar, Periyannan Solomon, Jeneeta Pandi, Thirunageswaran Manoharan, Vinosha Ravichandran, Anjali Mohandoss, Sonaimuthu Marudhupandi, Thangapandi SangGuanYou Prabhu, Narayanasamy Marimuthu Gold Anti-Bacterial Agents Metal Nanoparticles Humans Antioxidants Microbial Sensitivity Tests Green Chemistry Technology Zebrafish Animals Dose-Response Relationship, Drug Caulerpa Structure-Activity Relationship Drug Screening Assays, Antitumor Antineoplastic Agents Particle Size Cell Proliferation Molecular Structure HT29 Cells Photobacterium This research used an aqueous extract from Caulerpa sertularioides to convert gold ions, demonstrating the eco-friendliness, low toxicity, and cost-effectiveness of green nanoparticle synthesis. The formation of C. sertularioides-mediated gold nanoparticle (Cs-AuNPs) was authenticated by the UV-visible absorption peak at 538 nm. FT-IR identified functional groups responsible for reducing gold ions to Cs-AuNPs. XRD and electron microscopy (FESEM and HR-TEM) confirmed the face-centered cubic (fcc) structure and spherical shape, averaging 26.3 nm in size. The synthesized Cs-AuNPs were evaluated for antioxidant, antibacterial, and cytotoxic properties. Cs-AuNPs demonstrated a dose-dependent antioxidant activity. The antibacterial assay on Photobacterium damselae showed a concentration-dependent effect, with the highest activity of 21 mm at 100 μg/mL. The MTT experiment showed significant cytotoxic activity against HT-29 cells, with an IC of 15.44 μg/mL. Additionally, Cs-AuNPs exhibited no toxicity toward zebrafish embryos. These results suggest that C. sertularioides may serve as a sustainable source for producing AuNPs, which hold promise for biomedical applications as antibacterial and anticancer agents.