Long-term ecotoxicological effects of benzophenone-3 on the marine invertebrate, Crepidula onyx: Impacts on bioaccumulation, reproduction, shell integrity, condition indexes, and embryonic and larval development.
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Journal of hazardous materials
2025
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| _version_ | 1868266152131559425 |
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| author | Xi, Leyi Ng, Cheuk Fung Wong, Hei Ching Wong, Chris Kong Chu Wu, Rudolf Shiu Sun Tsang, Yiu Fai Thiyagarajan, Vengatesen Chiu, Jill Man Ying |
| author_facet | Xi, Leyi Ng, Cheuk Fung Wong, Hei Ching Wong, Chris Kong Chu Wu, Rudolf Shiu Sun Tsang, Yiu Fai Thiyagarajan, Vengatesen Chiu, Jill Man Ying Xi, Leyi Ng, Cheuk Fung Wong, Hei Ching Wong, Chris Kong Chu Wu, Rudolf Shiu Sun Tsang, Yiu Fai Thiyagarajan, Vengatesen Chiu, Jill Man Ying |
| collection | PubMed - marine biology |
| contents | Long-term ecotoxicological effects of benzophenone-3 on the marine invertebrate, Crepidula onyx: Impacts on bioaccumulation, reproduction, shell integrity, condition indexes, and embryonic and larval development. Xi, Leyi Ng, Cheuk Fung Wong, Hei Ching Wong, Chris Kong Chu Wu, Rudolf Shiu Sun Tsang, Yiu Fai Thiyagarajan, Vengatesen Chiu, Jill Man Ying Benzophenone-3 (BP-3), a widely used UV filter in personal care products, is recognized as an emerging endocrine disruptor, particularly impacting marine organisms. This study investigates BP-3's long-term effects on marine invertebrates, using the slipper limpet Crepidula onyx as a model species, focusing on bioaccumulation and reproductive and developmental impacts. Crepidula onyx was exposed to BP-3 concentrations of 1, 10, and 100 μg/L, reflecting realistic environmental levels, throughout their life cycle. Transcriptomic analyses explored the mechanisms affecting offspring. BP-3 exposure led to significant bioaccumulation, with metabolites BP-1 and BP-8 detected. BP-3 delayed sexual development, reduced fecundity, and altered condition indexes. Structural changes were observed in gonadal and gill tissues, and shell integrity was compromised, showing reduced thickness and fracture force. Embryonic and larval abnormalities were prevalent. Significant changes in gene expression related to nucleic acid metabolism and synthesis suggest mechanisms leading to developmental abnormalities. These results highlight potential threats posed to marine invertebrates by BP-3, emphasizing the urgent need for regulatory reassessment of BP-3 use. The study calls for further research into BP-3's molecular toxicity and ecological impacts, underscoring the necessity for updated environmental policies to protect marine ecosystems. |
| format | Artículo científico |
| id | pubmed_40946467 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of hazardous materials |
| record_format | pubmed |
| spellingShingle | Long-term ecotoxicological effects of benzophenone-3 on the marine invertebrate, Crepidula onyx: Impacts on bioaccumulation, reproduction, shell integrity, condition indexes, and embryonic and larval development. Xi, Leyi Ng, Cheuk Fung Wong, Hei Ching Wong, Chris Kong Chu Wu, Rudolf Shiu Sun Tsang, Yiu Fai Thiyagarajan, Vengatesen Chiu, Jill Man Ying Long-term ecotoxicological effects of benzophenone-3 on the marine invertebrate, Crepidula onyx: Impacts on bioaccumulation, reproduction, shell integrity, condition indexes, and embryonic and larval development. Xi, Leyi Ng, Cheuk Fung Wong, Hei Ching Wong, Chris Kong Chu Wu, Rudolf Shiu Sun Tsang, Yiu Fai Thiyagarajan, Vengatesen Chiu, Jill Man Ying Benzophenone-3 (BP-3), a widely used UV filter in personal care products, is recognized as an emerging endocrine disruptor, particularly impacting marine organisms. This study investigates BP-3's long-term effects on marine invertebrates, using the slipper limpet Crepidula onyx as a model species, focusing on bioaccumulation and reproductive and developmental impacts. Crepidula onyx was exposed to BP-3 concentrations of 1, 10, and 100 μg/L, reflecting realistic environmental levels, throughout their life cycle. Transcriptomic analyses explored the mechanisms affecting offspring. BP-3 exposure led to significant bioaccumulation, with metabolites BP-1 and BP-8 detected. BP-3 delayed sexual development, reduced fecundity, and altered condition indexes. Structural changes were observed in gonadal and gill tissues, and shell integrity was compromised, showing reduced thickness and fracture force. Embryonic and larval abnormalities were prevalent. Significant changes in gene expression related to nucleic acid metabolism and synthesis suggest mechanisms leading to developmental abnormalities. These results highlight potential threats posed to marine invertebrates by BP-3, emphasizing the urgent need for regulatory reassessment of BP-3 use. The study calls for further research into BP-3's molecular toxicity and ecological impacts, underscoring the necessity for updated environmental policies to protect marine ecosystems. |
| title | Long-term ecotoxicological effects of benzophenone-3 on the marine invertebrate, Crepidula onyx: Impacts on bioaccumulation, reproduction, shell integrity, condition indexes, and embryonic and larval development. |
| url | https://pubmed.ncbi.nlm.nih.gov/40946467/ |