Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.
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| Autores principales: | , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
bioRxiv : the preprint server for biology
2025
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| _version_ | 1868266152103247873 |
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| author | Herget, Ulrich Tran, Steven Singh, Chanpreet Oikonomou, Grigorios Ryu, Soojin Rotllant, Josep Prober, David A |
| author_facet | Herget, Ulrich Tran, Steven Singh, Chanpreet Oikonomou, Grigorios Ryu, Soojin Rotllant, Josep Prober, David A Herget, Ulrich Tran, Steven Singh, Chanpreet Oikonomou, Grigorios Ryu, Soojin Rotllant, Josep Prober, David A |
| collection | PubMed - marine biology |
| contents | Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons. Herget, Ulrich Tran, Steven Singh, Chanpreet Oikonomou, Grigorios Ryu, Soojin Rotllant, Josep Prober, David A Classical studies identified a critical role for the hypothalamus in regulating sleep and wake states, but few such hypothalamic neuronal populations have been identified. Here we describe a sleep-promoting population of hypothalamic neurons that expresses the neuropeptides QRFP and parathyroid hormone 4 (Pth4) in zebrafish. Optogenetic stimulation of these neurons results in a large increase in sleep that requires but not . Noradrenergic locus coeruleus (LC) neurons and serotonergic raphe neurons (RN) in the hindbrain express distinct , and genetic epistasis and cell ablation experiments revealed that Pth4 neuron-induced sleep is suppressed in mutants that lack noradrenaline in the LC or lack the serotonergic RN. Pth4 neuron-induced sleep is also suppressed in () mutants, possibly via -expressing neurons in the prethalamus that express . These results identify QRFP/Pth4 neurons as a novel hypothalamic sleep-promoting population and support a model in which distinct sleep- and wake-promoting hypothalamic populations act via monoaminergic neurons in the hindbrain to control vigilance state. |
| format | Artículo científico |
| id | pubmed_40964331 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | bioRxiv : the preprint server for biology |
| record_format | pubmed |
| spellingShingle | Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons. Herget, Ulrich Tran, Steven Singh, Chanpreet Oikonomou, Grigorios Ryu, Soojin Rotllant, Josep Prober, David A Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons. Herget, Ulrich Tran, Steven Singh, Chanpreet Oikonomou, Grigorios Ryu, Soojin Rotllant, Josep Prober, David A Classical studies identified a critical role for the hypothalamus in regulating sleep and wake states, but few such hypothalamic neuronal populations have been identified. Here we describe a sleep-promoting population of hypothalamic neurons that expresses the neuropeptides QRFP and parathyroid hormone 4 (Pth4) in zebrafish. Optogenetic stimulation of these neurons results in a large increase in sleep that requires but not . Noradrenergic locus coeruleus (LC) neurons and serotonergic raphe neurons (RN) in the hindbrain express distinct , and genetic epistasis and cell ablation experiments revealed that Pth4 neuron-induced sleep is suppressed in mutants that lack noradrenaline in the LC or lack the serotonergic RN. Pth4 neuron-induced sleep is also suppressed in () mutants, possibly via -expressing neurons in the prethalamus that express . These results identify QRFP/Pth4 neurons as a novel hypothalamic sleep-promoting population and support a model in which distinct sleep- and wake-promoting hypothalamic populations act via monoaminergic neurons in the hindbrain to control vigilance state. |
| title | Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons. |
| url | https://pubmed.ncbi.nlm.nih.gov/40964331/ |