Optimization of Dye and Plasticizer Concentrations in Halochromic Sensor Films for Rapid pH Response Using Bird-Inspired Metaheuristic Algorithms.
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| Format: | Artículo científico |
| Langue: | en |
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Sensors (Basel, Switzerland)
2025
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| _version_ | 1868266152098004995 |
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| author | Kim, Daeuk Concepcion, Ronnie S Sta Agueda, Joseph Rey H Marquez, Jubert C |
| author_facet | Kim, Daeuk Concepcion, Ronnie S Sta Agueda, Joseph Rey H Marquez, Jubert C Kim, Daeuk Concepcion, Ronnie S Sta Agueda, Joseph Rey H Marquez, Jubert C |
| collection | PubMed - marine biology |
| contents | Optimization of Dye and Plasticizer Concentrations in Halochromic Sensor Films for Rapid pH Response Using Bird-Inspired Metaheuristic Algorithms. Kim, Daeuk Concepcion, Ronnie S Sta Agueda, Joseph Rey H Marquez, Jubert C Hydrogen-Ion Concentration Algorithms Polyvinyl Alcohol Polyethylene Glycols Plasticizers Animals Coloring Agents Birds Bromthymol Blue Principal Component Analysis Biosensing Techniques Color The pH level of a wound environment is a crucial biomarker for monitoring wound healing, particularly in chronic wounds, where alkalinity (pH > 7) is linked to bacterial colonization and infection. This study developed and optimized a halochromic sensor film composed of polyvinyl alcohol (PVA), polyethylene glycol (PEG), and bromothymol blue (BTB) to enable rapid and reliable pH-responsive color transitions. Feature selection using Principal Component Analysis (PCA) and the ReliefF algorithm identified Hue, Saturation, and a as key features influencing pH responsivity. Optimization of BTB (0.01-0.05%) and PEG (6-10%) concentrations was conducted using bird-inspired metaheuristic algorithms, including the Parrot Optimizer (PO), Pelican Optimization Algorithm (POA), and Secretary Bird Optimization Algorithm (SBOA). While final fitness values showed negligible variation (188.595647 for GP-PO, 188.595634 for GP-POA, and 188.595634 for GP-SBOA), GP-PO demonstrated superior convergence and stability, efficiently identifying the optimal formulation (0.02% BTB, 6% PEG). The optimized film achieved a complete color transition within 3-5 min, a 23.15% reduction compared to the non-optimized formulation. Statistical analysis revealed that BTB concentration significantly affected response time ( = 0.01), while PEG concentration had no significant effect ( > 0.05). These findings highlight the potential of halochromic films for real-time, non-invasive pH monitoring in chronic wounds. |
| format | Artículo científico |
| id | pubmed_40969014 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Sensors (Basel, Switzerland) |
| record_format | pubmed |
| spellingShingle | Optimization of Dye and Plasticizer Concentrations in Halochromic Sensor Films for Rapid pH Response Using Bird-Inspired Metaheuristic Algorithms. Kim, Daeuk Concepcion, Ronnie S Sta Agueda, Joseph Rey H Marquez, Jubert C Hydrogen-Ion Concentration Algorithms Polyvinyl Alcohol Polyethylene Glycols Plasticizers Animals Coloring Agents Birds Bromthymol Blue Principal Component Analysis Biosensing Techniques Color Optimization of Dye and Plasticizer Concentrations in Halochromic Sensor Films for Rapid pH Response Using Bird-Inspired Metaheuristic Algorithms. Kim, Daeuk Concepcion, Ronnie S Sta Agueda, Joseph Rey H Marquez, Jubert C Hydrogen-Ion Concentration Algorithms Polyvinyl Alcohol Polyethylene Glycols Plasticizers Animals Coloring Agents Birds Bromthymol Blue Principal Component Analysis Biosensing Techniques Color The pH level of a wound environment is a crucial biomarker for monitoring wound healing, particularly in chronic wounds, where alkalinity (pH > 7) is linked to bacterial colonization and infection. This study developed and optimized a halochromic sensor film composed of polyvinyl alcohol (PVA), polyethylene glycol (PEG), and bromothymol blue (BTB) to enable rapid and reliable pH-responsive color transitions. Feature selection using Principal Component Analysis (PCA) and the ReliefF algorithm identified Hue, Saturation, and a as key features influencing pH responsivity. Optimization of BTB (0.01-0.05%) and PEG (6-10%) concentrations was conducted using bird-inspired metaheuristic algorithms, including the Parrot Optimizer (PO), Pelican Optimization Algorithm (POA), and Secretary Bird Optimization Algorithm (SBOA). While final fitness values showed negligible variation (188.595647 for GP-PO, 188.595634 for GP-POA, and 188.595634 for GP-SBOA), GP-PO demonstrated superior convergence and stability, efficiently identifying the optimal formulation (0.02% BTB, 6% PEG). The optimized film achieved a complete color transition within 3-5 min, a 23.15% reduction compared to the non-optimized formulation. Statistical analysis revealed that BTB concentration significantly affected response time ( = 0.01), while PEG concentration had no significant effect ( > 0.05). These findings highlight the potential of halochromic films for real-time, non-invasive pH monitoring in chronic wounds. |
| title | Optimization of Dye and Plasticizer Concentrations in Halochromic Sensor Films for Rapid pH Response Using Bird-Inspired Metaheuristic Algorithms. |
| topic | Hydrogen-Ion Concentration Algorithms Polyvinyl Alcohol Polyethylene Glycols Plasticizers Animals Coloring Agents Birds Bromthymol Blue Principal Component Analysis Biosensing Techniques Color |
| url | https://pubmed.ncbi.nlm.nih.gov/40969014/ |