First national study on genomic profiling of in United Arab Emirates (UAE) aquatic environments shows diverse Quinolone and Cephalosporin resistance.
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Environmental challenges (Amsterdam, Netherlands)
2025
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| _version_ | 1868266152098004993 |
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| author | Papadopoulou, A Moubareck, C A Ryder, D Powell, A L Stone, M Joseph, A W Khan, M A Light, E Verner-Jeffreys, D W Stahl, J H Le Quesne, W J F |
| author_facet | Papadopoulou, A Moubareck, C A Ryder, D Powell, A L Stone, M Joseph, A W Khan, M A Light, E Verner-Jeffreys, D W Stahl, J H Le Quesne, W J F Papadopoulou, A Moubareck, C A Ryder, D Powell, A L Stone, M Joseph, A W Khan, M A Light, E Verner-Jeffreys, D W Stahl, J H Le Quesne, W J F |
| collection | PubMed - marine biology |
| contents | First national study on genomic profiling of in United Arab Emirates (UAE) aquatic environments shows diverse Quinolone and Cephalosporin resistance. Papadopoulou, A Moubareck, C A Ryder, D Powell, A L Stone, M Joseph, A W Khan, M A Light, E Verner-Jeffreys, D W Stahl, J H Le Quesne, W J F Antimicrobial resistance (AMR) is a serious threat to human, animal and plant health, and over recent years the role of the aquatic environment as a hotspot and dissemination route for resistant bacteria has been increasingly recognised. The United Arab Emirates (UAE) has identified AMR as a critical area of concern; however, limited studies have been conducted regarding the presence of AMR in aquatic environments in the region. This study addresses this gap by conducting a national surveillance to better understand the prevalence of aquatic AMR. We investigated the phenotypic and genotypic resistances in () isolates (n= 256) from sewage impacted and unimpacted coastal waters and artificial lakes across the UAE. Multidrug resistance was observed in 34.2% of isolates, with 22.7% exhibiting resistance to 3 and 4 generation cephalosporins, cefotaxime and ceftazidime, including 16.6% displaying an extended-spectrum β-lactamase (ESBL) phenotype. Resistance to fluoroquinolones, macrolides, and carbapenems was also detected. Whole-genome sequencing (n=92) revealed a high prevalence of the virulence gene, as well as conjugative plasmids (IncF, IncA/C and IncY) carrying resistance determinants. Notably, and resistance genes were identified in 39% of sequenced isolates, while the gene was detected for the first time in a single isolate. These findings underscore the need for harmonised AMR surveillance and a regional monitoring framework to assess the environmental dissemination of AMR bacteria in a One Health context. |
| format | Artículo científico |
| id | pubmed_40969202 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Environmental challenges (Amsterdam, Netherlands) |
| record_format | pubmed |
| spellingShingle | First national study on genomic profiling of in United Arab Emirates (UAE) aquatic environments shows diverse Quinolone and Cephalosporin resistance. Papadopoulou, A Moubareck, C A Ryder, D Powell, A L Stone, M Joseph, A W Khan, M A Light, E Verner-Jeffreys, D W Stahl, J H Le Quesne, W J F First national study on genomic profiling of in United Arab Emirates (UAE) aquatic environments shows diverse Quinolone and Cephalosporin resistance. Papadopoulou, A Moubareck, C A Ryder, D Powell, A L Stone, M Joseph, A W Khan, M A Light, E Verner-Jeffreys, D W Stahl, J H Le Quesne, W J F Antimicrobial resistance (AMR) is a serious threat to human, animal and plant health, and over recent years the role of the aquatic environment as a hotspot and dissemination route for resistant bacteria has been increasingly recognised. The United Arab Emirates (UAE) has identified AMR as a critical area of concern; however, limited studies have been conducted regarding the presence of AMR in aquatic environments in the region. This study addresses this gap by conducting a national surveillance to better understand the prevalence of aquatic AMR. We investigated the phenotypic and genotypic resistances in () isolates (n= 256) from sewage impacted and unimpacted coastal waters and artificial lakes across the UAE. Multidrug resistance was observed in 34.2% of isolates, with 22.7% exhibiting resistance to 3 and 4 generation cephalosporins, cefotaxime and ceftazidime, including 16.6% displaying an extended-spectrum β-lactamase (ESBL) phenotype. Resistance to fluoroquinolones, macrolides, and carbapenems was also detected. Whole-genome sequencing (n=92) revealed a high prevalence of the virulence gene, as well as conjugative plasmids (IncF, IncA/C and IncY) carrying resistance determinants. Notably, and resistance genes were identified in 39% of sequenced isolates, while the gene was detected for the first time in a single isolate. These findings underscore the need for harmonised AMR surveillance and a regional monitoring framework to assess the environmental dissemination of AMR bacteria in a One Health context. |
| title | First national study on genomic profiling of in United Arab Emirates (UAE) aquatic environments shows diverse Quinolone and Cephalosporin resistance. |
| url | https://pubmed.ncbi.nlm.nih.gov/40969202/ |