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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40987204/ |
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| _version_ | 1868266149496487937 |
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| author | Shahlaei, Mona Afkhami, Hamed Ahmadieh-Yazdi, Amirhossein Mirmazloumi, Seyed Hashem Sahraei, Seyedeh Saeideh Akbari, Mohammad Yang, Piao Manoochehri, Hamed Tanzadehpanah, Hamid Mahaki, Hanie Sundararaman, Aravind Mohan, Sreedivya Sheykhhasan, Mohsen Al-Musawi, Sharafaldin Dama, Paola |
| author_facet | Shahlaei, Mona Afkhami, Hamed Ahmadieh-Yazdi, Amirhossein Mirmazloumi, Seyed Hashem Sahraei, Seyedeh Saeideh Akbari, Mohammad Yang, Piao Manoochehri, Hamed Tanzadehpanah, Hamid Mahaki, Hanie Sundararaman, Aravind Mohan, Sreedivya Sheykhhasan, Mohsen Al-Musawi, Sharafaldin Dama, Paola Shahlaei, Mona Afkhami, Hamed Ahmadieh-Yazdi, Amirhossein Mirmazloumi, Seyed Hashem Sahraei, Seyedeh Saeideh Akbari, Mohammad Yang, Piao Manoochehri, Hamed Tanzadehpanah, Hamid Mahaki, Hanie Sundararaman, Aravind Mohan, Sreedivya Sheykhhasan, Mohsen Al-Musawi, Sharafaldin Dama, Paola |
| collection | PubMed - marine biology |
| contents | Exosomes in Alzheimer's disease: From pathogenesis to therapeutics-A comprehensive review of diagnostic and drug delivery applications. Shahlaei, Mona Afkhami, Hamed Ahmadieh-Yazdi, Amirhossein Mirmazloumi, Seyed Hashem Sahraei, Seyedeh Saeideh Akbari, Mohammad Yang, Piao Manoochehri, Hamed Tanzadehpanah, Hamid Mahaki, Hanie Sundararaman, Aravind Mohan, Sreedivya Sheykhhasan, Mohsen Al-Musawi, Sharafaldin Dama, Paola Alzheimer Disease Exosomes Humans Drug Delivery Systems Animals Biomarkers Amyloid beta-Peptides Blood-Brain Barrier Neuroprotective Agents Alzheimer's disease (AD) is still a major unmet medical challenge, with limited treatment options and a critical need for early diagnostics. Exosomes, nanoscale extracellular vesicles with a lipid bilayer, are pivotal players in intercellular communication and promising tools for AD management. Their unique ability to cross the bloodbrain barrier, low immunogenicity, and ability for cargo delivery make them ideal candidates for targeted drug delivery. This review comprehensively examines the biology of exosomes-including their structure, biogenesis, release, and uptake-and evaluates advanced methods for their isolation, purification, and characterization. We highlight their dual role in AD pathogenesis, where they can propagate pathological proteins such as amyloid-β and tau, and in therapeutic applications, where engineered exosomes deliver neuroprotective agents. Furthermore, exosomal biomarkers in biofluids show significant potential for noninvasive early diagnosis. Recent advances in loading strategies and surface engineering have been discussed, alongside challenges in scalability and safety. This synthesis bridges current knowledge with future directions, emphasizing the translational potential of exosomes in AD therapeutics and diagnostics. |
| format | Artículo científico |
| id | pubmed_40987204 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie |
| record_format | pubmed |
| spellingShingle | Exosomes in Alzheimer's disease: From pathogenesis to therapeutics-A comprehensive review of diagnostic and drug delivery applications. Shahlaei, Mona Afkhami, Hamed Ahmadieh-Yazdi, Amirhossein Mirmazloumi, Seyed Hashem Sahraei, Seyedeh Saeideh Akbari, Mohammad Yang, Piao Manoochehri, Hamed Tanzadehpanah, Hamid Mahaki, Hanie Sundararaman, Aravind Mohan, Sreedivya Sheykhhasan, Mohsen Al-Musawi, Sharafaldin Dama, Paola Alzheimer Disease Exosomes Humans Drug Delivery Systems Animals Biomarkers Amyloid beta-Peptides Blood-Brain Barrier Neuroprotective Agents Exosomes in Alzheimer's disease: From pathogenesis to therapeutics-A comprehensive review of diagnostic and drug delivery applications. Shahlaei, Mona Afkhami, Hamed Ahmadieh-Yazdi, Amirhossein Mirmazloumi, Seyed Hashem Sahraei, Seyedeh Saeideh Akbari, Mohammad Yang, Piao Manoochehri, Hamed Tanzadehpanah, Hamid Mahaki, Hanie Sundararaman, Aravind Mohan, Sreedivya Sheykhhasan, Mohsen Al-Musawi, Sharafaldin Dama, Paola Alzheimer Disease Exosomes Humans Drug Delivery Systems Animals Biomarkers Amyloid beta-Peptides Blood-Brain Barrier Neuroprotective Agents Alzheimer's disease (AD) is still a major unmet medical challenge, with limited treatment options and a critical need for early diagnostics. Exosomes, nanoscale extracellular vesicles with a lipid bilayer, are pivotal players in intercellular communication and promising tools for AD management. Their unique ability to cross the bloodbrain barrier, low immunogenicity, and ability for cargo delivery make them ideal candidates for targeted drug delivery. This review comprehensively examines the biology of exosomes-including their structure, biogenesis, release, and uptake-and evaluates advanced methods for their isolation, purification, and characterization. We highlight their dual role in AD pathogenesis, where they can propagate pathological proteins such as amyloid-β and tau, and in therapeutic applications, where engineered exosomes deliver neuroprotective agents. Furthermore, exosomal biomarkers in biofluids show significant potential for noninvasive early diagnosis. Recent advances in loading strategies and surface engineering have been discussed, alongside challenges in scalability and safety. This synthesis bridges current knowledge with future directions, emphasizing the translational potential of exosomes in AD therapeutics and diagnostics. |
| title | Exosomes in Alzheimer's disease: From pathogenesis to therapeutics-A comprehensive review of diagnostic and drug delivery applications. |
| topic | Alzheimer Disease Exosomes Humans Drug Delivery Systems Animals Biomarkers Amyloid beta-Peptides Blood-Brain Barrier Neuroprotective Agents |
| url | https://pubmed.ncbi.nlm.nih.gov/40987204/ |