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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of natural products
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40998300/ |
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Table of Contents:
- Actinomycetoquinones A-E, Anthraquinone-γ-Pyrones Discovered from Marine-Derived sp. Bacterium. Zhang, Fan Roberts, Christopher D Lee, Tae Hyun Braun, Doug R Bennett, Zachary D Chanana, Shaurya Guo, Song Ananiev, Gene E Guzei, Ilia A Rajski, Scott R Brunold, Thomas C Bugni, Tim S Anthraquinones Molecular Structure Pyrones Microbial Sensitivity Tests Anti-Bacterial Agents Methicillin-Resistant Staphylococcus aureus Escherichia coli Marine Biology Crystallography, X-Ray Actinobacteria Nuclear Magnetic Resonance, Biomolecular Facilitated by LC-MS-PCA metabolomics methods and effective molecular networking for strain prioritization and dereplication, five new anthraquinone-γ-pyrones, actinomycetoquinones A-E (-), were isolated from a marine-derived sp. bacterium. The structures of - were elucidated by analysis of their HRMS and NMR spectroscopic data. The absolute configuration of was unequivocally determined by single-crystal X-ray diffraction analysis using Cu Kα radiation. Actinomycetoquinone C exhibited antibacterial activity against methicillin-resistant (MRSA) and with MIC values of 1 and 4 μg/mL, respectively.