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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine drugs
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41003306/ |
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Table of Contents:
- OSMAC-Driven Discovery of Six New Alkaloids from the Cold-Seep-Derived Fungus HDN21-0307. Huang, Xinsheng Wu, Jiajin Zhou, Luning Wang, Zhengjie Che, Qian Chen, Liangzhen Wang, Wenxue Zhu, Tianjiao Li, Dehai Talaromyces Alkaloids Molecular Structure Free Radical Scavengers Drug Discovery Six new alkaloid compounds, including two rare aromatic nitrile compounds talaronitriles A-B (-), a novel oxime-functionalized azadiphilone analogue talarooxime A (), a new phenylhydrazone alkaloid talarohydrazone E (), and two new dipeptide compounds talarodipeptides A-B (-), were isolated from the deep-sea cold-seep-derived fungus HDN21-0307 via OSMAC approach. Compound is the first natural naphthalene compound with cyano groups. Compound represents the first natural product containing an oxime-functionalized azadiphilone scaffold. Their structures and absolute configurations were elucidated through spectroscopic data analysis and quantum chemical calculations. Notably, compound demonstrated moderate DPPH free-radical-scavenging activity, with an IC value of 29.41 μM.