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| Main Authors: | , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
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Archives of toxicology
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41006718/ |
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| author | Chen, Qian Deng, Congshuang Huang, Xiaoshan Wang, Aili Xu, Nan Cao, Kaixun Yang, Min Li, Shang Lu, Qiumin Gong, Guiyi Lee, Simon Ming-Yuen |
| author_facet | Chen, Qian Deng, Congshuang Huang, Xiaoshan Wang, Aili Xu, Nan Cao, Kaixun Yang, Min Li, Shang Lu, Qiumin Gong, Guiyi Lee, Simon Ming-Yuen Chen, Qian Deng, Congshuang Huang, Xiaoshan Wang, Aili Xu, Nan Cao, Kaixun Yang, Min Li, Shang Lu, Qiumin Gong, Guiyi Lee, Simon Ming-Yuen |
| collection | PubMed - marine biology |
| contents | A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R. Chen, Qian Deng, Congshuang Huang, Xiaoshan Wang, Aili Xu, Nan Cao, Kaixun Yang, Min Li, Shang Lu, Qiumin Gong, Guiyi Lee, Simon Ming-Yuen Animals Pentylenetetrazole Zebrafish Seizures Mice Anticonvulsants Male Neuropeptides Hippocampus Neuropeptide Y Memory Disorders Disease Models, Animal Epilepsy Cell Line Epilepsy is a prevalent neurological disorder characterized by recurrent and unprovoked seizures. Despite the availability of anti-epileptic drugs (AEDs), a significant number of patients are still suffering from drug-resistant epilepsy. Neuropeptide Y (NPY) signaling system has emerged as a potential target for the development of anti-epileptic drugs due to its modulation of epileptic activity. In this study, we investigated the therapeutic potential of our previously discovered Scleractinia-derived NPY-like peptide (TpNPY) in seizure disorders. The anticonvulsant effects of TpNPY were evaluated using PTZ-induced seizures in zebrafish and mice in vivo. Furthermore, the underlying molecular mechanisms of TpNPY were assessed using glutamate-induced excitotoxicity models in HT22 mouse hippocampal cells in vitro. Our findings indicated that TpNPY could alleviate PTZ-induced seizure behavior, reduce the expression of seizure-associated immediate-early genes and the production of Reactive Oxygen Species (ROS) in zebrafish. In mice, TpNPY improved seizure behaviors, decreased inflammatory cytokine levels, and ameliorated abnormal glial activation in a PTZ kindling epileptic model. Besides, the administration of TpNPY could attenuate the PTZ-induced anxiety levels and improve recognition memory deficits. Moreover, TpNPY promotes neurogenesis and neural synaptic plasticity through the BDNF/TrkB signaling pathway. Additionally, TpNPY restored cell injury and attenuated oxidative stress in glutamate-challenged HT22 cells through the Nrf2/HO-1 signaling pathway. These results highlight the potential therapeutic efficacy of TpNPY in the treatment of seizures and provide new insights into the development of coral-derived anti-epileptic peptide-based drugs. |
| format | Artículo científico |
| id | pubmed_41006718 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Archives of toxicology |
| record_format | pubmed |
| spellingShingle | A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R. Chen, Qian Deng, Congshuang Huang, Xiaoshan Wang, Aili Xu, Nan Cao, Kaixun Yang, Min Li, Shang Lu, Qiumin Gong, Guiyi Lee, Simon Ming-Yuen Animals Pentylenetetrazole Zebrafish Seizures Mice Anticonvulsants Male Neuropeptides Hippocampus Neuropeptide Y Memory Disorders Disease Models, Animal Epilepsy Cell Line A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R. Chen, Qian Deng, Congshuang Huang, Xiaoshan Wang, Aili Xu, Nan Cao, Kaixun Yang, Min Li, Shang Lu, Qiumin Gong, Guiyi Lee, Simon Ming-Yuen Animals Pentylenetetrazole Zebrafish Seizures Mice Anticonvulsants Male Neuropeptides Hippocampus Neuropeptide Y Memory Disorders Disease Models, Animal Epilepsy Cell Line Epilepsy is a prevalent neurological disorder characterized by recurrent and unprovoked seizures. Despite the availability of anti-epileptic drugs (AEDs), a significant number of patients are still suffering from drug-resistant epilepsy. Neuropeptide Y (NPY) signaling system has emerged as a potential target for the development of anti-epileptic drugs due to its modulation of epileptic activity. In this study, we investigated the therapeutic potential of our previously discovered Scleractinia-derived NPY-like peptide (TpNPY) in seizure disorders. The anticonvulsant effects of TpNPY were evaluated using PTZ-induced seizures in zebrafish and mice in vivo. Furthermore, the underlying molecular mechanisms of TpNPY were assessed using glutamate-induced excitotoxicity models in HT22 mouse hippocampal cells in vitro. Our findings indicated that TpNPY could alleviate PTZ-induced seizure behavior, reduce the expression of seizure-associated immediate-early genes and the production of Reactive Oxygen Species (ROS) in zebrafish. In mice, TpNPY improved seizure behaviors, decreased inflammatory cytokine levels, and ameliorated abnormal glial activation in a PTZ kindling epileptic model. Besides, the administration of TpNPY could attenuate the PTZ-induced anxiety levels and improve recognition memory deficits. Moreover, TpNPY promotes neurogenesis and neural synaptic plasticity through the BDNF/TrkB signaling pathway. Additionally, TpNPY restored cell injury and attenuated oxidative stress in glutamate-challenged HT22 cells through the Nrf2/HO-1 signaling pathway. These results highlight the potential therapeutic efficacy of TpNPY in the treatment of seizures and provide new insights into the development of coral-derived anti-epileptic peptide-based drugs. |
| title | A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R. |
| topic | Animals Pentylenetetrazole Zebrafish Seizures Mice Anticonvulsants Male Neuropeptides Hippocampus Neuropeptide Y Memory Disorders Disease Models, Animal Epilepsy Cell Line |
| url | https://pubmed.ncbi.nlm.nih.gov/41006718/ |