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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
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2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41010051/ |
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Table of Contents:
- Genetic Diversity and Selection of in Clariid Catfish from Thailand: Implications for Breeding and Conservation. Nguyen, Ton Huu Duc Chalermwong, Piangjai Patta, Chananya Jaito, Wattanawan Singchat, Worapong Panthum, Thitipong Budi, Trifan Sriphairoj, Kednapat Hatachote, Sittichai Srisapoome, Prapansak Muangmai, Narongrit Griffin, Darren K Antunes, Agostinho Duengkae, Prateep Srikulnath, Kornsorn Animals Thailand Phylogeny Catfishes Genetic Variation Selection, Genetic Genes, MHC Class I Histocompatibility Antigens Class I Alleles Breeding Fish Proteins Understanding variabilities in the Major Histocompatibility Complex class I () gene is essential for evaluating immunogenetic diversity in clariid catfish. plays a critical role in immune defense by presenting endogenous antigens to cytotoxic T cells. Therefore, we aimed to investigate the genetic diversity, selection patterns, and phylogenetic relationships of alleles in three important clariid catfish species (, , and ) across wild and hatchery populations in Thailand. Targeted next-generation sequencing of a 174 bp fragment partial exon 6 of gene was performed, along with phylogenetic analyses, neutrality tests and / analyses. Overall, 91 novel alleles were identified in 674 individuals, all of which were novel (100% novelty), with none matching existing reference sequences, thereby revealing extensive variation in population-specific variants. Phylogenetic analyses revealed allele sharing among species, which was consistent with balanced selection. Neutrality tests and / analyses provided evidence of both purifying and diversifying selection, with episodic positive selection detected at multiple codon sites associated with the antigen-binding α1 domain. Distinct selection patterns among populations, influenced by local environmental conditions and human pressures, along with high allele richness, are reflected in the diversity of immunogenetic variations. These findings provide critical insights into immune adaptation and highlight the potential of as a functional marker for genetic monitoring. Although a causal relationship between polymorphism and disease resistance is debated, studies suggest associations with pathogen survival, indicating future implications for aquaculture breeding and conservation, particularly in marker-assisted selection for broodstock management in Thailand.