Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Pharmaceuticals (Basel, Switzerland)
2025
|
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41011115/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266146730344450 |
|---|---|
| author | Chang, Sue-Joan Chen, Yung-Chia Chang, Yun-Ching Cheng, Chung-Che Chan, Yin-Ching |
| author_facet | Chang, Sue-Joan Chen, Yung-Chia Chang, Yun-Ching Cheng, Chung-Che Chan, Yin-Ching Chang, Sue-Joan Chen, Yung-Chia Chang, Yun-Ching Cheng, Chung-Che Chan, Yin-Ching |
| collection | PubMed - marine biology |
| contents | ETAS, a Standardized Extract of Stem, Alleviates Sarcopenia via Regulating Protein Turnover and Mitochondrial Quality. Chang, Sue-Joan Chen, Yung-Chia Chang, Yun-Ching Cheng, Chung-Che Chan, Yin-Ching : ETAS, a standardized extract of stem, has been found to alleviate cognitive impairment in senescence-accelerated mice prone 8 (SAMP8) and is now considered a functional food in aging. The present study aimed to investigate the impacts of ETAS on relieving aging-related muscle atrophy in SAMP8 mice. : The SAMP8 mice were fed a regular diet supplemented with 200 or 1000 mg/kg BW ETAS50 for 12 weeks. Grip strength, muscle mass, and molecular markers of protein synthesis, degradation, and mitochondrial quality were assessed. : We found that ETAS significantly increased grip strength and muscle mass in SAMP8 mice. At the molecular level, ETAS significantly upregulated protein synthesis via PI3K/Akt/mTOR/p70S6K and downregulated protein degradation via FoxO1a/atrogin-1 and MuRF-1 and myostatin via NFκB expression. In addition, ETAS improved mitochondrial quality via promoting mitochondrial biogenesis genes, oxidative respiration genes, fusion/fission genes, PGC1α, and PINK1 proteins and maintained the autophagic flux via reducing ATG13, LC3-II/LC3-I, and p62. : ETAS exerts beneficial effects on sarcopenia by modulating the positive protein turnover and improving mitochondrial quality in aging. |
| format | Artículo científico |
| id | pubmed_41011115 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Pharmaceuticals (Basel, Switzerland) |
| record_format | pubmed |
| spellingShingle | ETAS, a Standardized Extract of Stem, Alleviates Sarcopenia via Regulating Protein Turnover and Mitochondrial Quality. Chang, Sue-Joan Chen, Yung-Chia Chang, Yun-Ching Cheng, Chung-Che Chan, Yin-Ching ETAS, a Standardized Extract of Stem, Alleviates Sarcopenia via Regulating Protein Turnover and Mitochondrial Quality. Chang, Sue-Joan Chen, Yung-Chia Chang, Yun-Ching Cheng, Chung-Che Chan, Yin-Ching : ETAS, a standardized extract of stem, has been found to alleviate cognitive impairment in senescence-accelerated mice prone 8 (SAMP8) and is now considered a functional food in aging. The present study aimed to investigate the impacts of ETAS on relieving aging-related muscle atrophy in SAMP8 mice. : The SAMP8 mice were fed a regular diet supplemented with 200 or 1000 mg/kg BW ETAS50 for 12 weeks. Grip strength, muscle mass, and molecular markers of protein synthesis, degradation, and mitochondrial quality were assessed. : We found that ETAS significantly increased grip strength and muscle mass in SAMP8 mice. At the molecular level, ETAS significantly upregulated protein synthesis via PI3K/Akt/mTOR/p70S6K and downregulated protein degradation via FoxO1a/atrogin-1 and MuRF-1 and myostatin via NFκB expression. In addition, ETAS improved mitochondrial quality via promoting mitochondrial biogenesis genes, oxidative respiration genes, fusion/fission genes, PGC1α, and PINK1 proteins and maintained the autophagic flux via reducing ATG13, LC3-II/LC3-I, and p62. : ETAS exerts beneficial effects on sarcopenia by modulating the positive protein turnover and improving mitochondrial quality in aging. |
| title | ETAS, a Standardized Extract of Stem, Alleviates Sarcopenia via Regulating Protein Turnover and Mitochondrial Quality. |
| url | https://pubmed.ncbi.nlm.nih.gov/41011115/ |