Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Toxics
2025
|
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41012394/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266146726150146 |
|---|---|
| author | Gao, Jiahao Zhou, Tianyang Chen, Zuchun Zhang, Ning Guo, Yusong Wang, Zhongduo Shi, Wenjun Dong, Zhongdian |
| author_facet | Gao, Jiahao Zhou, Tianyang Chen, Zuchun Zhang, Ning Guo, Yusong Wang, Zhongduo Shi, Wenjun Dong, Zhongdian Gao, Jiahao Zhou, Tianyang Chen, Zuchun Zhang, Ning Guo, Yusong Wang, Zhongduo Shi, Wenjun Dong, Zhongdian |
| collection | PubMed - marine biology |
| contents | Toxic Effects of BPAF on Marine Medaka () During Embryo-Larval Stages. Gao, Jiahao Zhou, Tianyang Chen, Zuchun Zhang, Ning Guo, Yusong Wang, Zhongduo Shi, Wenjun Dong, Zhongdian BPAF (Bisphenol AF), one of the primary substitutes for BPA (Bisphenol A), is widely used in the production of plastics, optical fibers, and other materials. During the use of these products, BPAF inevitably enters the environment and exerts toxic effects on animal growth, development, reproduction, immunity, neurology, and genetics. This study employed marine medaka () as the experimental model to evaluate the toxicological impacts of BPAF on early development. Embryos were exposed to four BPAF concentrations (0, 1 μg/L, 10 μg/L, and 100 μg/L) for 14 days (embryonic to larval stages), followed by phenotypic measurements, behavioral analysis, and gene expression detection. The results demonstrated that BPAF exposure induced developmental malformations and reduced survival rates in marine medaka embryos, with embryo survival negatively correlated with BPAF concentrations. Additionally, BPAF significantly decreased embryonic heart rates, and the 100 μg/L BPAF group exhibited prolonged embryo hatching time and reduced hatching success. In newly hatched larvae, BPAF exposure led to decreased body length, reduced heart rates, and significant suppression of swimming activity, characterized by increased resting time and reduced swimming distance. BPAF exposure altered the expression levels of genes associated with cardiovascular function (e.g., , ), the HPT axis (e.g., , , , , ), and neurodevelopment (e.g., , , ) in the medaka larvae. These transcriptional perturbations are proposed as potential molecular mechanisms underlying the observed phenotypic effects, including reduced heart rates and suppressed swimming behavior in the study. Molecularly, BPAF exposure significantly disrupted the expression of genes related to the cardiovascular system, HPT axis, and nervous system. |
| format | Artículo científico |
| id | pubmed_41012394 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Toxics |
| record_format | pubmed |
| spellingShingle | Toxic Effects of BPAF on Marine Medaka () During Embryo-Larval Stages. Gao, Jiahao Zhou, Tianyang Chen, Zuchun Zhang, Ning Guo, Yusong Wang, Zhongduo Shi, Wenjun Dong, Zhongdian Toxic Effects of BPAF on Marine Medaka () During Embryo-Larval Stages. Gao, Jiahao Zhou, Tianyang Chen, Zuchun Zhang, Ning Guo, Yusong Wang, Zhongduo Shi, Wenjun Dong, Zhongdian BPAF (Bisphenol AF), one of the primary substitutes for BPA (Bisphenol A), is widely used in the production of plastics, optical fibers, and other materials. During the use of these products, BPAF inevitably enters the environment and exerts toxic effects on animal growth, development, reproduction, immunity, neurology, and genetics. This study employed marine medaka () as the experimental model to evaluate the toxicological impacts of BPAF on early development. Embryos were exposed to four BPAF concentrations (0, 1 μg/L, 10 μg/L, and 100 μg/L) for 14 days (embryonic to larval stages), followed by phenotypic measurements, behavioral analysis, and gene expression detection. The results demonstrated that BPAF exposure induced developmental malformations and reduced survival rates in marine medaka embryos, with embryo survival negatively correlated with BPAF concentrations. Additionally, BPAF significantly decreased embryonic heart rates, and the 100 μg/L BPAF group exhibited prolonged embryo hatching time and reduced hatching success. In newly hatched larvae, BPAF exposure led to decreased body length, reduced heart rates, and significant suppression of swimming activity, characterized by increased resting time and reduced swimming distance. BPAF exposure altered the expression levels of genes associated with cardiovascular function (e.g., , ), the HPT axis (e.g., , , , , ), and neurodevelopment (e.g., , , ) in the medaka larvae. These transcriptional perturbations are proposed as potential molecular mechanisms underlying the observed phenotypic effects, including reduced heart rates and suppressed swimming behavior in the study. Molecularly, BPAF exposure significantly disrupted the expression of genes related to the cardiovascular system, HPT axis, and nervous system. |
| title | Toxic Effects of BPAF on Marine Medaka () During Embryo-Larval Stages. |
| url | https://pubmed.ncbi.nlm.nih.gov/41012394/ |