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| Main Authors: | , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
iScience
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41019367/ |
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| _version_ | 1868266146716712961 |
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| author | Fan, Bin Guo, Jiamin Lei, Caixia Yang, Sen Meng, Zining Peng, Junyao Yang, Yongjian Shen, Yubang Li, Yuanyou Wang, Le |
| author_facet | Fan, Bin Guo, Jiamin Lei, Caixia Yang, Sen Meng, Zining Peng, Junyao Yang, Yongjian Shen, Yubang Li, Yuanyou Wang, Le Fan, Bin Guo, Jiamin Lei, Caixia Yang, Sen Meng, Zining Peng, Junyao Yang, Yongjian Shen, Yubang Li, Yuanyou Wang, Le |
| collection | PubMed - marine biology |
| contents | Haplotype-resolved genomics identifies as a candidate master sex-determining gene in golden trevally (). Fan, Bin Guo, Jiamin Lei, Caixia Yang, Sen Meng, Zining Peng, Junyao Yang, Yongjian Shen, Yubang Li, Yuanyou Wang, Le Teleost fish exhibit diverse genetic sex determination systems, offering opportunities to understand its genetic basis and insights into sex chromosome evolution. The golden trevally (), a commercially important Carangidae species, was studied to uncover its sex determination mechanism. We generated haplotype-resolved, chromosome-level genome assemblies for both sexes and identified a ZW system with a ∼90 kb sex-determining region (SDR) on Chr1. Within the SDR, is uniquely expressed from the W allele prior to gonadal differentiation. A ∼1-kb upstream region of harbors fixed variants between sexes. Reporter gene assays reveal that these variants reduce promoter activity in the Z allele, likely silencing . This suggests that allelic diversification led to the emergence of as the master sex-determining gene. Minimal divergence in the SDR implies a recent origin of sex chromosomes. These findings provide key genomic resources and insights into sex determination evolution in teleosts. |
| format | Artículo científico |
| id | pubmed_41019367 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | iScience |
| record_format | pubmed |
| spellingShingle | Haplotype-resolved genomics identifies as a candidate master sex-determining gene in golden trevally (). Fan, Bin Guo, Jiamin Lei, Caixia Yang, Sen Meng, Zining Peng, Junyao Yang, Yongjian Shen, Yubang Li, Yuanyou Wang, Le Haplotype-resolved genomics identifies as a candidate master sex-determining gene in golden trevally (). Fan, Bin Guo, Jiamin Lei, Caixia Yang, Sen Meng, Zining Peng, Junyao Yang, Yongjian Shen, Yubang Li, Yuanyou Wang, Le Teleost fish exhibit diverse genetic sex determination systems, offering opportunities to understand its genetic basis and insights into sex chromosome evolution. The golden trevally (), a commercially important Carangidae species, was studied to uncover its sex determination mechanism. We generated haplotype-resolved, chromosome-level genome assemblies for both sexes and identified a ZW system with a ∼90 kb sex-determining region (SDR) on Chr1. Within the SDR, is uniquely expressed from the W allele prior to gonadal differentiation. A ∼1-kb upstream region of harbors fixed variants between sexes. Reporter gene assays reveal that these variants reduce promoter activity in the Z allele, likely silencing . This suggests that allelic diversification led to the emergence of as the master sex-determining gene. Minimal divergence in the SDR implies a recent origin of sex chromosomes. These findings provide key genomic resources and insights into sex determination evolution in teleosts. |
| title | Haplotype-resolved genomics identifies as a candidate master sex-determining gene in golden trevally (). |
| url | https://pubmed.ncbi.nlm.nih.gov/41019367/ |