Chlorobactine A, a Dimeric Dichlorated Metabolite from Marine-Derived NAK03196.
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Organic letters
2025
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| _version_ | 1868266146707275776 |
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| author | Zhang, Guodong Shi, Jing Zhang, Chao Wang, Wen Yang, Xiao Xiong, Zijun Ma, Shuai Wang, Rong Guo, Zhikai Jiao, Ruihua |
| author_facet | Zhang, Guodong Shi, Jing Zhang, Chao Wang, Wen Yang, Xiao Xiong, Zijun Ma, Shuai Wang, Rong Guo, Zhikai Jiao, Ruihua Zhang, Guodong Shi, Jing Zhang, Chao Wang, Wen Yang, Xiao Xiong, Zijun Ma, Shuai Wang, Rong Guo, Zhikai Jiao, Ruihua |
| collection | PubMed - marine biology |
| contents | Chlorobactine A, a Dimeric Dichlorated Metabolite from Marine-Derived NAK03196. Zhang, Guodong Shi, Jing Zhang, Chao Wang, Wen Yang, Xiao Xiong, Zijun Ma, Shuai Wang, Rong Guo, Zhikai Jiao, Ruihua Streptomyces Molecular Structure Crystallography, X-Ray Using the one strain many compounds (OSMAC) strategy and guided by LC-MS results, we explored the metabolites of marine algae-derived strain NAK03196 and discovered a new class of molecules with an unexpected skeleton, chlorobactine A (). Its structure was determined by 1D and 2D NMR spectroscopy, HR-ESI-MS, single-crystal X-ray diffraction analysis (Cu Kα), and ECD calculation. Chlorobactine A () contains dichlorine atoms and possesses a unique [6/6/6] tricyclic fused skeleton structure. Meanwhile, a plausible biosynthetic pathway for was proposed based on the molecular structures and bioinformatic analysis. |
| format | Artículo científico |
| id | pubmed_41025430 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Organic letters |
| record_format | pubmed |
| spellingShingle | Chlorobactine A, a Dimeric Dichlorated Metabolite from Marine-Derived NAK03196. Zhang, Guodong Shi, Jing Zhang, Chao Wang, Wen Yang, Xiao Xiong, Zijun Ma, Shuai Wang, Rong Guo, Zhikai Jiao, Ruihua Streptomyces Molecular Structure Crystallography, X-Ray Chlorobactine A, a Dimeric Dichlorated Metabolite from Marine-Derived NAK03196. Zhang, Guodong Shi, Jing Zhang, Chao Wang, Wen Yang, Xiao Xiong, Zijun Ma, Shuai Wang, Rong Guo, Zhikai Jiao, Ruihua Streptomyces Molecular Structure Crystallography, X-Ray Using the one strain many compounds (OSMAC) strategy and guided by LC-MS results, we explored the metabolites of marine algae-derived strain NAK03196 and discovered a new class of molecules with an unexpected skeleton, chlorobactine A (). Its structure was determined by 1D and 2D NMR spectroscopy, HR-ESI-MS, single-crystal X-ray diffraction analysis (Cu Kα), and ECD calculation. Chlorobactine A () contains dichlorine atoms and possesses a unique [6/6/6] tricyclic fused skeleton structure. Meanwhile, a plausible biosynthetic pathway for was proposed based on the molecular structures and bioinformatic analysis. |
| title | Chlorobactine A, a Dimeric Dichlorated Metabolite from Marine-Derived NAK03196. |
| topic | Streptomyces Molecular Structure Crystallography, X-Ray |
| url | https://pubmed.ncbi.nlm.nih.gov/41025430/ |