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| Main Authors: | , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Organic letters
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41025430/ |
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Table of Contents:
- Chlorobactine A, a Dimeric Dichlorated Metabolite from Marine-Derived NAK03196. Zhang, Guodong Shi, Jing Zhang, Chao Wang, Wen Yang, Xiao Xiong, Zijun Ma, Shuai Wang, Rong Guo, Zhikai Jiao, Ruihua Streptomyces Molecular Structure Crystallography, X-Ray Using the one strain many compounds (OSMAC) strategy and guided by LC-MS results, we explored the metabolites of marine algae-derived strain NAK03196 and discovered a new class of molecules with an unexpected skeleton, chlorobactine A (). Its structure was determined by 1D and 2D NMR spectroscopy, HR-ESI-MS, single-crystal X-ray diffraction analysis (Cu Kα), and ECD calculation. Chlorobactine A () contains dichlorine atoms and possesses a unique [6/6/6] tricyclic fused skeleton structure. Meanwhile, a plausible biosynthetic pathway for was proposed based on the molecular structures and bioinformatic analysis.