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| Autori principali: | , , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
International journal of biological macromolecules
2025
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| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/41038483/ |
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Sommario:
- Sulfated polysaccharide from Apostichopus japonicus and its inhibition effects on Helicobacter pylori in vitro and in vivo. Gai, Xinyue Zhang, Hui Sun, Yongjun Zhao, Wen Zhang, Miansong Cui, Tingting Du, Hongfang Liu, Xue Jia, Airong Animals Helicobacter pylori Polysaccharides Stichopus Mice Sulfates Anti-Bacterial Agents Helicobacter Infections Gastrointestinal Microbiome High-bioactivity sea cucumber polysaccharides (SCPs) exhibit significant potential for food industrial applications. However, research on SCPs with inhibitory effects against Helicobacter pylori (Hp) remains limited. Searching for SCPs with potent Hp inhibition is of great importance. In this study, a sulfated polysaccharide AJP was extracted from Apostichopus japonicus. Composition analysis indicated that AJP contained 45.99 ± 1.41 % total sugar, 4.89 ± 0.22 % protein, 24.22 ± 0.46 % sulfate ester, 4.65 ± 0.06 % amino sugar, and 3.44 ± 0.34 % uronic acid. In addition, AJP had a high fucose ratio of 58.29 % (mol%) and a molecular weight of 116-1069 kDa. Antibacterial assays demonstrated that AJP possessed inhibitory effects against Hp in vitro. Moreover, AJP significantly alleviated gastric inflammation in Hp-infected mice and effectively reduced the colonization levels of Hp in both the Prevention (P