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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
bioRxiv : the preprint server for biology
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41040342/ |
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Table of Contents:
- Regional Signaling Controls Stem Cell-Mediated Regeneration in an Invertebrate Chordate. Gordon, Tal Levy, Tom Yu, Chester Jiamu Rosental, Benyamin Lubeck, Lauren Manni, Lucia Weissman, Irving L Voskoboynik, Ayelet Many tissues harbor quiescent stem cells that activate after injury, yet how local signals regulate this transition is not well understood. The solitary ascidian provides a unique model, as upper body fragments regenerate while lower fragments fail to do so. By comparing these regenerative and non-regenerative contexts, we reveal striking differences in transcriptional dynamics and signaling environments. Combining flow cytometry, scRNA-seq, transplantation, and fate mapping, we identified a candidate stem cell population with robust proliferative and differentiation potential following transplantation. However, regenerative capacity does not simply reflect stem cell abundance, but instead depends on region-specific signaling cues. Local expression of metabolic, immune and differentiation-related factors further underscores the importance of spatially distinct environments in shaping outcomes. Our findings show how a shared injury response can diverge into regeneration versus failure, highlighting principles that may be leveraged to enhance tissue repair in other systems.