A coral peptide with bactericidal activity against a global marine pathogen, .
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PubMed
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| Autori principali: | , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
iScience
2025
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| Accesso online: | |
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| _version_ | 1868266144181256193 |
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| author | Aoyama, Kako Okai, Masahiko Ogawa, Nobuhiro Fukumaru, Riko Ishida, Masami Inoue, Koji Takagi, Toshiyuki |
| author_facet | Aoyama, Kako Okai, Masahiko Ogawa, Nobuhiro Fukumaru, Riko Ishida, Masami Inoue, Koji Takagi, Toshiyuki Aoyama, Kako Okai, Masahiko Ogawa, Nobuhiro Fukumaru, Riko Ishida, Masami Inoue, Koji Takagi, Toshiyuki |
| collection | PubMed - marine biology |
| contents | A coral peptide with bactericidal activity against a global marine pathogen, . Aoyama, Kako Okai, Masahiko Ogawa, Nobuhiro Fukumaru, Riko Ishida, Masami Inoue, Koji Takagi, Toshiyuki Rising seawater temperatures weaken coral immunity and increase the virulence of the coral pathogen . Here, we identified digitiferin, an antimicrobial peptide (AMP), in the coral, . Recombinant digitiferin showed antibacterial activity against both Gram-positive and -negative bacteria. A 3D structural model and microscopic observations revealed that digitiferin damages bacterial surfaces. However, initial growth inhibition tests in 1.5% (w/v) NaCl showed no effect on pathogens. We found that digitiferin is secreted into mucus, where NaCl concentrations are lower than in seawater. Hence, we hypothesized that it is active against pathogens in low-salt environments. By re-evaluating under low-salt conditions, we discovered that digitiferin kills species. Digitiferin homologs were found in multiple coral species, suggesting that digitiferin may serve as a first-line defense mechanism and determine disease susceptibility in corals. These findings enhance our understanding of coral-pathogen interactions and will facilitate the development of techniques to overcome disease. |
| format | Artículo científico |
| id | pubmed_41054529 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | iScience |
| record_format | pubmed |
| spellingShingle | A coral peptide with bactericidal activity against a global marine pathogen, . Aoyama, Kako Okai, Masahiko Ogawa, Nobuhiro Fukumaru, Riko Ishida, Masami Inoue, Koji Takagi, Toshiyuki A coral peptide with bactericidal activity against a global marine pathogen, . Aoyama, Kako Okai, Masahiko Ogawa, Nobuhiro Fukumaru, Riko Ishida, Masami Inoue, Koji Takagi, Toshiyuki Rising seawater temperatures weaken coral immunity and increase the virulence of the coral pathogen . Here, we identified digitiferin, an antimicrobial peptide (AMP), in the coral, . Recombinant digitiferin showed antibacterial activity against both Gram-positive and -negative bacteria. A 3D structural model and microscopic observations revealed that digitiferin damages bacterial surfaces. However, initial growth inhibition tests in 1.5% (w/v) NaCl showed no effect on pathogens. We found that digitiferin is secreted into mucus, where NaCl concentrations are lower than in seawater. Hence, we hypothesized that it is active against pathogens in low-salt environments. By re-evaluating under low-salt conditions, we discovered that digitiferin kills species. Digitiferin homologs were found in multiple coral species, suggesting that digitiferin may serve as a first-line defense mechanism and determine disease susceptibility in corals. These findings enhance our understanding of coral-pathogen interactions and will facilitate the development of techniques to overcome disease. |
| title | A coral peptide with bactericidal activity against a global marine pathogen, . |
| url | https://pubmed.ncbi.nlm.nih.gov/41054529/ |