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| Autores principales: | , , , , , , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Journal of hazardous materials
2025
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| Materias: | |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/41056719/ |
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| _version_ | 1868266144178110466 |
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| author | Huang, Xinyu He, Yuanzhen Zhang, Lu Chen, Jia Zhang, Guoqing Zhang, Zhiguo Huang, Wei Ma, Lukuo Cheng, Fangping Wang, Yuntao Zhu, Xinyu Ju, Feng |
| author_facet | Huang, Xinyu He, Yuanzhen Zhang, Lu Chen, Jia Zhang, Guoqing Zhang, Zhiguo Huang, Wei Ma, Lukuo Cheng, Fangping Wang, Yuntao Zhu, Xinyu Ju, Feng Huang, Xinyu He, Yuanzhen Zhang, Lu Chen, Jia Zhang, Guoqing Zhang, Zhiguo Huang, Wei Ma, Lukuo Cheng, Fangping Wang, Yuntao Zhu, Xinyu Ju, Feng |
| collection | PubMed - marine biology |
| contents | Deciphering structuring mechanism and increased health risk of antibiotic resistome from a coastal river basin to the downstream estuary and bay under anthropogenic disturbances. Huang, Xinyu He, Yuanzhen Zhang, Lu Chen, Jia Zhang, Guoqing Zhang, Zhiguo Huang, Wei Ma, Lukuo Cheng, Fangping Wang, Yuntao Zhu, Xinyu Ju, Feng Rivers Estuaries China Anti-Bacterial Agents Bays Drug Resistance, Microbial Microbiota Anthropogenic Effects Water Pollutants, Chemical Genes, Bacterial Bacteria beta-Lactamases Environmental Monitoring Environmental microbiome harbors antibiotic resistance genes (ARGs) integrable with human and animal resistomes. Despite the prevailing concerns on the continental-scale contamination of estuaries with ARGs, the resistome structuring mechanisms and health risks in hydrodynamically-disturbed coastal ecosystems are unknown. This study showed that the resistome structure shifted from the Qiantang River Basin via its estuary to Hangzhou Bay in eastern China, driven by both biotic (e.g., microbial community and mobile genetic elements) and abiotic factors (e.g., pharmaceutical and personal care products, and tidal hydrodynamics), suggesting the combined role of vertical and horizontal transmission in shaping antibiotic resistome. The notable abundance increases (by at least 1.8 times) of extended-spectrum β-lactamases (e.g., CTX-M-65, SHV-67), carbapenemase (e.g., KPC-2), and mobile ARGs of synthetic veterinary antibiotics (e.g., florfenicol-resistant floR and sulfonamide-resistant sul1) reflected the prevalence of clinically important antibiotic resistance in the estuary and contributed to the observed elevation in resistome risks. Further discovery of macrolide resistance gene macB and extended-spectrum β-lactamase TEM-116 in uncultured indigenous Nitrospirota strains implicated the alarming invasion of clinically important antibiotic resistance into the coastal sediment resistomes. These results emphasize the prominent role of anthropogenic disturbances in shaping resistome structure and escalating health risks in coastal ecosystems. |
| format | Artículo científico |
| id | pubmed_41056719 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of hazardous materials |
| record_format | pubmed |
| spellingShingle | Deciphering structuring mechanism and increased health risk of antibiotic resistome from a coastal river basin to the downstream estuary and bay under anthropogenic disturbances. Huang, Xinyu He, Yuanzhen Zhang, Lu Chen, Jia Zhang, Guoqing Zhang, Zhiguo Huang, Wei Ma, Lukuo Cheng, Fangping Wang, Yuntao Zhu, Xinyu Ju, Feng Rivers Estuaries China Anti-Bacterial Agents Bays Drug Resistance, Microbial Microbiota Anthropogenic Effects Water Pollutants, Chemical Genes, Bacterial Bacteria beta-Lactamases Environmental Monitoring Deciphering structuring mechanism and increased health risk of antibiotic resistome from a coastal river basin to the downstream estuary and bay under anthropogenic disturbances. Huang, Xinyu He, Yuanzhen Zhang, Lu Chen, Jia Zhang, Guoqing Zhang, Zhiguo Huang, Wei Ma, Lukuo Cheng, Fangping Wang, Yuntao Zhu, Xinyu Ju, Feng Rivers Estuaries China Anti-Bacterial Agents Bays Drug Resistance, Microbial Microbiota Anthropogenic Effects Water Pollutants, Chemical Genes, Bacterial Bacteria beta-Lactamases Environmental Monitoring Environmental microbiome harbors antibiotic resistance genes (ARGs) integrable with human and animal resistomes. Despite the prevailing concerns on the continental-scale contamination of estuaries with ARGs, the resistome structuring mechanisms and health risks in hydrodynamically-disturbed coastal ecosystems are unknown. This study showed that the resistome structure shifted from the Qiantang River Basin via its estuary to Hangzhou Bay in eastern China, driven by both biotic (e.g., microbial community and mobile genetic elements) and abiotic factors (e.g., pharmaceutical and personal care products, and tidal hydrodynamics), suggesting the combined role of vertical and horizontal transmission in shaping antibiotic resistome. The notable abundance increases (by at least 1.8 times) of extended-spectrum β-lactamases (e.g., CTX-M-65, SHV-67), carbapenemase (e.g., KPC-2), and mobile ARGs of synthetic veterinary antibiotics (e.g., florfenicol-resistant floR and sulfonamide-resistant sul1) reflected the prevalence of clinically important antibiotic resistance in the estuary and contributed to the observed elevation in resistome risks. Further discovery of macrolide resistance gene macB and extended-spectrum β-lactamase TEM-116 in uncultured indigenous Nitrospirota strains implicated the alarming invasion of clinically important antibiotic resistance into the coastal sediment resistomes. These results emphasize the prominent role of anthropogenic disturbances in shaping resistome structure and escalating health risks in coastal ecosystems. |
| title | Deciphering structuring mechanism and increased health risk of antibiotic resistome from a coastal river basin to the downstream estuary and bay under anthropogenic disturbances. |
| topic | Rivers Estuaries China Anti-Bacterial Agents Bays Drug Resistance, Microbial Microbiota Anthropogenic Effects Water Pollutants, Chemical Genes, Bacterial Bacteria beta-Lactamases Environmental Monitoring |
| url | https://pubmed.ncbi.nlm.nih.gov/41056719/ |