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| Format: | Artículo científico |
| Sprache: | en |
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BMJ open
2025
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/41083299/ |
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| author | O'Brien, Katherine Grifferty, Grace Shirley, Hugh George, Santosh Binkley, Abigail Orriols, Adrienne M Espinola Coombs, Philip Williams, Abigail L Wong, Morgan G Roe, Sophia Wallace, Fiona Tschoepe, Kathleen Hirsch, Jason L Wamai, Richard |
| author_facet | O'Brien, Katherine Grifferty, Grace Shirley, Hugh George, Santosh Binkley, Abigail Orriols, Adrienne M Espinola Coombs, Philip Williams, Abigail L Wong, Morgan G Roe, Sophia Wallace, Fiona Tschoepe, Kathleen Hirsch, Jason L Wamai, Richard O'Brien, Katherine Grifferty, Grace Shirley, Hugh George, Santosh Binkley, Abigail Orriols, Adrienne M Espinola Coombs, Philip Williams, Abigail L Wong, Morgan G Roe, Sophia Wallace, Fiona Tschoepe, Kathleen Hirsch, Jason L Wamai, Richard |
| collection | PubMed - marine biology |
| contents | The leishmaniases in Kenya: a scoping review sub-analysis of diagnostics. O'Brien, Katherine Grifferty, Grace Shirley, Hugh George, Santosh Binkley, Abigail Orriols, Adrienne M Espinola Coombs, Philip Williams, Abigail L Wong, Morgan G Roe, Sophia Wallace, Fiona Tschoepe, Kathleen Hirsch, Jason L Wamai, Richard Kenya Humans Leishmaniasis Leishmaniasis, Cutaneous Leishmaniasis poses a significant public health problem in Kenya, where effective case management and treatment rely on accurate diagnosis. This review aims to summarise the research landscape on leishmaniasis diagnostics in Kenya and identify gaps. This scoping review expands a previously published scoping review on leishmaniasis in Kenya to further analyse studies focusing on diagnostics. The field of diagnostics was chosen because of recent pushes for novel tools and because of the role timely diagnosis plays in disease elimination. A comprehensive search of PubMed, Embase via Embase.com, Web of Science Core Collection, the Cochrane Library, ClinicalTrials.gov, WHO ICTRP and the Pan African Clinical Trials Registry was conducted, covering studies up to 5 January 2024. After dual, blind screening with conflict resolution by a third reviewer, 41 studies were included in the review. These studies examined a range of diagnostic tools; however most were assessed in one or few studies, and none evaluated real-time PCR. Additional gaps in the research landscape include a lack of diagnostics for cutaneous leishmaniasis and post-kala-azar dermal leishmaniasis in Kenya, outdated literature surrounding the Direct Agglutination Test and randomised trials for any diagnostic tool. Future research should focus on solidifying the validity and reliability of diagnostic tools in the Kenyan context and updating previous work. |
| format | Artículo científico |
| id | pubmed_41083299 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | BMJ open |
| record_format | pubmed |
| spellingShingle | The leishmaniases in Kenya: a scoping review sub-analysis of diagnostics. O'Brien, Katherine Grifferty, Grace Shirley, Hugh George, Santosh Binkley, Abigail Orriols, Adrienne M Espinola Coombs, Philip Williams, Abigail L Wong, Morgan G Roe, Sophia Wallace, Fiona Tschoepe, Kathleen Hirsch, Jason L Wamai, Richard Kenya Humans Leishmaniasis Leishmaniasis, Cutaneous The leishmaniases in Kenya: a scoping review sub-analysis of diagnostics. O'Brien, Katherine Grifferty, Grace Shirley, Hugh George, Santosh Binkley, Abigail Orriols, Adrienne M Espinola Coombs, Philip Williams, Abigail L Wong, Morgan G Roe, Sophia Wallace, Fiona Tschoepe, Kathleen Hirsch, Jason L Wamai, Richard Kenya Humans Leishmaniasis Leishmaniasis, Cutaneous Leishmaniasis poses a significant public health problem in Kenya, where effective case management and treatment rely on accurate diagnosis. This review aims to summarise the research landscape on leishmaniasis diagnostics in Kenya and identify gaps. This scoping review expands a previously published scoping review on leishmaniasis in Kenya to further analyse studies focusing on diagnostics. The field of diagnostics was chosen because of recent pushes for novel tools and because of the role timely diagnosis plays in disease elimination. A comprehensive search of PubMed, Embase via Embase.com, Web of Science Core Collection, the Cochrane Library, ClinicalTrials.gov, WHO ICTRP and the Pan African Clinical Trials Registry was conducted, covering studies up to 5 January 2024. After dual, blind screening with conflict resolution by a third reviewer, 41 studies were included in the review. These studies examined a range of diagnostic tools; however most were assessed in one or few studies, and none evaluated real-time PCR. Additional gaps in the research landscape include a lack of diagnostics for cutaneous leishmaniasis and post-kala-azar dermal leishmaniasis in Kenya, outdated literature surrounding the Direct Agglutination Test and randomised trials for any diagnostic tool. Future research should focus on solidifying the validity and reliability of diagnostic tools in the Kenyan context and updating previous work. |
| title | The leishmaniases in Kenya: a scoping review sub-analysis of diagnostics. |
| topic | Kenya Humans Leishmaniasis Leishmaniasis, Cutaneous |
| url | https://pubmed.ncbi.nlm.nih.gov/41083299/ |