Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Bioorganic chemistry
2025
|
| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41086727/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266141746462720 |
|---|---|
| author | Falanga, Andrea Patrizia Mahal, Ahmed Marzano, Maria D'Errico, Stefano Secondo, Agnese Piccialli, Ilaria Borbone, Nicola |
| author_facet | Falanga, Andrea Patrizia Mahal, Ahmed Marzano, Maria D'Errico, Stefano Secondo, Agnese Piccialli, Ilaria Borbone, Nicola Falanga, Andrea Patrizia Mahal, Ahmed Marzano, Maria D'Errico, Stefano Secondo, Agnese Piccialli, Ilaria Borbone, Nicola |
| collection | PubMed - marine biology |
| contents | The evolving chemistry of cADPR analogues: from marine discovery to calcium signaling tools. Falanga, Andrea Patrizia Mahal, Ahmed Marzano, Maria D'Errico, Stefano Secondo, Agnese Piccialli, Ilaria Borbone, Nicola Humans Cyclic ADP-Ribose Calcium Signaling Structure-Activity Relationship Molecular Structure Drug Discovery Animals Jurkat Cells Calcium Aquatic Organisms Cyclic adenosine diphosphate ribose (cADPR) is a key second messenger that regulates intracellular Ca homeostasis via ryanodine receptor (RyR)-dependent pathways. However, its limited membrane permeability and susceptibility to hydrolysis hinder its application as a molecular probe or therapeutic agent. To address these concerns, extensive efforts have focused on the total synthesis of cADPR analogues, aiming to obtain chemically stable and cell-permeable derivatives with tailored properties. Among the various cellular systems expressing a functional cADPR signaling machinery, Jurkat and neuronal cells are of particular interest, as dysregulation of intracellular calcium levels has been observed in these cellular systems in the contexts of HIV infection and neuroblastoma development, respectively. Accordingly, this review highlights the recent advances in the design and synthesis of cADPR analogues, offering new insights in structure-activity relationship (SAR) studies in Jurkat and neuronal cells, and emphasizing the importance of balancing structural stability, cellular uptake, and receptor affinity to achieve an effective Ca mobilization. Overall, the findings discussed herein contribute to a deeper understanding of cADPR chemical biology and provide a synthetic platform for the rational design of cutting-edge Ca-modulating agents with potential diagnostic and therapeutic applications. |
| format | Artículo científico |
| id | pubmed_41086727 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Bioorganic chemistry |
| record_format | pubmed |
| spellingShingle | The evolving chemistry of cADPR analogues: from marine discovery to calcium signaling tools. Falanga, Andrea Patrizia Mahal, Ahmed Marzano, Maria D'Errico, Stefano Secondo, Agnese Piccialli, Ilaria Borbone, Nicola Humans Cyclic ADP-Ribose Calcium Signaling Structure-Activity Relationship Molecular Structure Drug Discovery Animals Jurkat Cells Calcium Aquatic Organisms The evolving chemistry of cADPR analogues: from marine discovery to calcium signaling tools. Falanga, Andrea Patrizia Mahal, Ahmed Marzano, Maria D'Errico, Stefano Secondo, Agnese Piccialli, Ilaria Borbone, Nicola Humans Cyclic ADP-Ribose Calcium Signaling Structure-Activity Relationship Molecular Structure Drug Discovery Animals Jurkat Cells Calcium Aquatic Organisms Cyclic adenosine diphosphate ribose (cADPR) is a key second messenger that regulates intracellular Ca homeostasis via ryanodine receptor (RyR)-dependent pathways. However, its limited membrane permeability and susceptibility to hydrolysis hinder its application as a molecular probe or therapeutic agent. To address these concerns, extensive efforts have focused on the total synthesis of cADPR analogues, aiming to obtain chemically stable and cell-permeable derivatives with tailored properties. Among the various cellular systems expressing a functional cADPR signaling machinery, Jurkat and neuronal cells are of particular interest, as dysregulation of intracellular calcium levels has been observed in these cellular systems in the contexts of HIV infection and neuroblastoma development, respectively. Accordingly, this review highlights the recent advances in the design and synthesis of cADPR analogues, offering new insights in structure-activity relationship (SAR) studies in Jurkat and neuronal cells, and emphasizing the importance of balancing structural stability, cellular uptake, and receptor affinity to achieve an effective Ca mobilization. Overall, the findings discussed herein contribute to a deeper understanding of cADPR chemical biology and provide a synthetic platform for the rational design of cutting-edge Ca-modulating agents with potential diagnostic and therapeutic applications. |
| title | The evolving chemistry of cADPR analogues: from marine discovery to calcium signaling tools. |
| topic | Humans Cyclic ADP-Ribose Calcium Signaling Structure-Activity Relationship Molecular Structure Drug Discovery Animals Jurkat Cells Calcium Aquatic Organisms |
| url | https://pubmed.ncbi.nlm.nih.gov/41086727/ |