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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Nutrients
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41097142/ |
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| _version_ | 1868266138854490113 |
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| author | Tahan Zadeh, Navid Knop, Mirjam Ulrich, Lisa Marie Bruchhaus, Iris Lang, Roman Lüersen, Kai Rimbach, Gerald Roeder, Thomas |
| author_facet | Tahan Zadeh, Navid Knop, Mirjam Ulrich, Lisa Marie Bruchhaus, Iris Lang, Roman Lüersen, Kai Rimbach, Gerald Roeder, Thomas Tahan Zadeh, Navid Knop, Mirjam Ulrich, Lisa Marie Bruchhaus, Iris Lang, Roman Lüersen, Kai Rimbach, Gerald Roeder, Thomas |
| collection | PubMed - marine biology |
| contents | Sex-Specific Lifespan Extension and Anti-Obesogenic Effects of Extract Through Tor Signaling Modulation in . Tahan Zadeh, Navid Knop, Mirjam Ulrich, Lisa Marie Bruchhaus, Iris Lang, Roman Lüersen, Kai Rimbach, Gerald Roeder, Thomas Animals Longevity Plant Extracts Female Male Signal Transduction Chenopodiaceae TOR Serine-Threonine Kinases Drosophila Proteins Sex Factors Drosophila Drosophila melanogaster Diet, High-Fat : Some marine plants and algae are known to exert health benefits. However, the long-term effects and underlying mechanisms of these health benefits are still poorly understood. For this reason, we have investigated an extract from the marsh samphire for its life-prolonging potential. : We investigated the effect of an aqueous extract of (SEE) on the lifespan of several wild-type strains of . In addition, we used deficient flies to elucidate the mechanism of the life-prolonging effects. Finally, we comprehensively phenotyped the treated animals. : Supplementing a standard diet with SEE extended the lifespan of different laboratory strains by up to a third (37% in and 19% in ). A total of 0.05% of SEE were ineffective, whereas 0.2% induced robust lifespan prolongation. This effect was strictly sex-specific, as the SEE application was completely ineffective in males, while prolonging life in females. We found that the body fat content of SEE-treated female flies was lower compared to controls. The extract also positively impacted the lifespan of flies fed a high-fat diet but not a high-sugar diet. SEE exhibited a lipase-inhibitory activity in vitro. Moreover, SEE counteracted aging-associated loss of intestinal barrier integrity. The sex-specific lifespan extensions induced by the SEE entirely depended on functional Tor signaling in the flies. Tissue-specific silencing of the Tor signaling pathway in different cellular compartments of the intestine reduced, but did not altogether abolish, the lifespan-prolonging effect in females. : SEE is a promising candidate for a health-promoting intervention, as it induces lifespan-prolonging and anti-obesogenic effects in a sex-specific manner. These effects depend on functional Tor and partially on FoxO signaling. Future studies should identify the active compounds in the extract. |
| format | Artículo científico |
| id | pubmed_41097142 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Nutrients |
| record_format | pubmed |
| spellingShingle | Sex-Specific Lifespan Extension and Anti-Obesogenic Effects of Extract Through Tor Signaling Modulation in . Tahan Zadeh, Navid Knop, Mirjam Ulrich, Lisa Marie Bruchhaus, Iris Lang, Roman Lüersen, Kai Rimbach, Gerald Roeder, Thomas Animals Longevity Plant Extracts Female Male Signal Transduction Chenopodiaceae TOR Serine-Threonine Kinases Drosophila Proteins Sex Factors Drosophila Drosophila melanogaster Diet, High-Fat Sex-Specific Lifespan Extension and Anti-Obesogenic Effects of Extract Through Tor Signaling Modulation in . Tahan Zadeh, Navid Knop, Mirjam Ulrich, Lisa Marie Bruchhaus, Iris Lang, Roman Lüersen, Kai Rimbach, Gerald Roeder, Thomas Animals Longevity Plant Extracts Female Male Signal Transduction Chenopodiaceae TOR Serine-Threonine Kinases Drosophila Proteins Sex Factors Drosophila Drosophila melanogaster Diet, High-Fat : Some marine plants and algae are known to exert health benefits. However, the long-term effects and underlying mechanisms of these health benefits are still poorly understood. For this reason, we have investigated an extract from the marsh samphire for its life-prolonging potential. : We investigated the effect of an aqueous extract of (SEE) on the lifespan of several wild-type strains of . In addition, we used deficient flies to elucidate the mechanism of the life-prolonging effects. Finally, we comprehensively phenotyped the treated animals. : Supplementing a standard diet with SEE extended the lifespan of different laboratory strains by up to a third (37% in and 19% in ). A total of 0.05% of SEE were ineffective, whereas 0.2% induced robust lifespan prolongation. This effect was strictly sex-specific, as the SEE application was completely ineffective in males, while prolonging life in females. We found that the body fat content of SEE-treated female flies was lower compared to controls. The extract also positively impacted the lifespan of flies fed a high-fat diet but not a high-sugar diet. SEE exhibited a lipase-inhibitory activity in vitro. Moreover, SEE counteracted aging-associated loss of intestinal barrier integrity. The sex-specific lifespan extensions induced by the SEE entirely depended on functional Tor signaling in the flies. Tissue-specific silencing of the Tor signaling pathway in different cellular compartments of the intestine reduced, but did not altogether abolish, the lifespan-prolonging effect in females. : SEE is a promising candidate for a health-promoting intervention, as it induces lifespan-prolonging and anti-obesogenic effects in a sex-specific manner. These effects depend on functional Tor and partially on FoxO signaling. Future studies should identify the active compounds in the extract. |
| title | Sex-Specific Lifespan Extension and Anti-Obesogenic Effects of Extract Through Tor Signaling Modulation in . |
| topic | Animals Longevity Plant Extracts Female Male Signal Transduction Chenopodiaceae TOR Serine-Threonine Kinases Drosophila Proteins Sex Factors Drosophila Drosophila melanogaster Diet, High-Fat |
| url | https://pubmed.ncbi.nlm.nih.gov/41097142/ |