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| Format: | Artículo científico |
| Langue: | en |
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Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
2026
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| Accès en ligne: | https://pubmed.ncbi.nlm.nih.gov/41115600/ |
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| author | Pérez-Pereira, Ariana Carvalho, Ana R Costa, Pedro A Castro, Bruno B Carrola, João S Gonçalves, Virgínia M F Ribeiro, Ana R L Almeida, Ana Sofia Fernandes, Carla Tiritan, Maria E Ribeiro, Cláudia |
| author_facet | Pérez-Pereira, Ariana Carvalho, Ana R Costa, Pedro A Castro, Bruno B Carrola, João S Gonçalves, Virgínia M F Ribeiro, Ana R L Almeida, Ana Sofia Fernandes, Carla Tiritan, Maria E Ribeiro, Cláudia Pérez-Pereira, Ariana Carvalho, Ana R Costa, Pedro A Castro, Bruno B Carrola, João S Gonçalves, Virgínia M F Ribeiro, Ana R L Almeida, Ana Sofia Fernandes, Carla Tiritan, Maria E Ribeiro, Cláudia |
| collection | PubMed - marine biology |
| contents | Enantioselective toxicity of 3,4-methylenedioxypyrovalerone in Daphnia magna: Assessment of morphophysiological, behavioural, biochemical and reproductive responses. Pérez-Pereira, Ariana Carvalho, Ana R Costa, Pedro A Castro, Bruno B Carrola, João S Gonçalves, Virgínia M F Ribeiro, Ana R L Almeida, Ana Sofia Fernandes, Carla Tiritan, Maria E Ribeiro, Cláudia Animals Daphnia Pyrrolidines Benzodioxoles Reproduction Stereoisomerism Water Pollutants, Chemical Behavior, Animal Synthetic Cathinone Dose-Response Relationship, Drug Daphnia magna The enantioselective toxicity of 3,4-methylenedioxypyrovalerone (MDPV) remains unexplored in freshwater organisms. This study investigated the effects of MDPV racemate and its enantiomers in Daphnia magna using two approaches: (i) an 8-day sub-chronic assay focused on early development stages; and (ii) the standard 21-day reproduction assay. The sub-chronic assay tested two environmental concentrations (0.10 and 1.0 μg L), for both racemate or individual enantiomers, and a higher sublethal concentration of 10 μg L for the racemate. Survival, morphophysiological, behavioural, reproductive, and biochemical responses were evaluated. The reproduction assay tested concentrations from 0.10 to 1.79 μg L, and evaluated survival, body size, and reproductive effects. Sub-chronic exposure to 10 μg L (R,S)-MDPV decreased survival. MDPV racemate and its enantiomers changed morphophysiological parameters, except for body growth. In juveniles, the heart area increased with 0.10 μg L of (R)-MDPV whereas the heart size decreased with 0.10 and 1.0 μg L of (S)-MDPV. Enantioselective effects were observed in swimming behaviour: (S)-MDPV increased speed and (R)-MDPV increased active time. No effects were observed in biochemical (except in reactive oxygen species for (S)-MDPV) and early reproductive parameters. The reproduction assay revealed enhanced growth in all MDPV forms (except at 0.56 μg L). A nonsignificant reduction in survival to the higher concentrations of (R)-MDPV was accompanied by reduced reproductive output (at 1.00 and 1.79 μg L) and intrinsic rate of population increase (at 1.79 μg L). Our findings suggest that, in general, (S)-MDPV triggers more severe sub-chronic effects, whereas (R)-MDPV is associated with harmful effects for longer time exposure. |
| format | Artículo científico |
| id | pubmed_41115600 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP |
| record_format | pubmed |
| spellingShingle | Enantioselective toxicity of 3,4-methylenedioxypyrovalerone in Daphnia magna: Assessment of morphophysiological, behavioural, biochemical and reproductive responses. Pérez-Pereira, Ariana Carvalho, Ana R Costa, Pedro A Castro, Bruno B Carrola, João S Gonçalves, Virgínia M F Ribeiro, Ana R L Almeida, Ana Sofia Fernandes, Carla Tiritan, Maria E Ribeiro, Cláudia Animals Daphnia Pyrrolidines Benzodioxoles Reproduction Stereoisomerism Water Pollutants, Chemical Behavior, Animal Synthetic Cathinone Dose-Response Relationship, Drug Daphnia magna Enantioselective toxicity of 3,4-methylenedioxypyrovalerone in Daphnia magna: Assessment of morphophysiological, behavioural, biochemical and reproductive responses. Pérez-Pereira, Ariana Carvalho, Ana R Costa, Pedro A Castro, Bruno B Carrola, João S Gonçalves, Virgínia M F Ribeiro, Ana R L Almeida, Ana Sofia Fernandes, Carla Tiritan, Maria E Ribeiro, Cláudia Animals Daphnia Pyrrolidines Benzodioxoles Reproduction Stereoisomerism Water Pollutants, Chemical Behavior, Animal Synthetic Cathinone Dose-Response Relationship, Drug Daphnia magna The enantioselective toxicity of 3,4-methylenedioxypyrovalerone (MDPV) remains unexplored in freshwater organisms. This study investigated the effects of MDPV racemate and its enantiomers in Daphnia magna using two approaches: (i) an 8-day sub-chronic assay focused on early development stages; and (ii) the standard 21-day reproduction assay. The sub-chronic assay tested two environmental concentrations (0.10 and 1.0 μg L), for both racemate or individual enantiomers, and a higher sublethal concentration of 10 μg L for the racemate. Survival, morphophysiological, behavioural, reproductive, and biochemical responses were evaluated. The reproduction assay tested concentrations from 0.10 to 1.79 μg L, and evaluated survival, body size, and reproductive effects. Sub-chronic exposure to 10 μg L (R,S)-MDPV decreased survival. MDPV racemate and its enantiomers changed morphophysiological parameters, except for body growth. In juveniles, the heart area increased with 0.10 μg L of (R)-MDPV whereas the heart size decreased with 0.10 and 1.0 μg L of (S)-MDPV. Enantioselective effects were observed in swimming behaviour: (S)-MDPV increased speed and (R)-MDPV increased active time. No effects were observed in biochemical (except in reactive oxygen species for (S)-MDPV) and early reproductive parameters. The reproduction assay revealed enhanced growth in all MDPV forms (except at 0.56 μg L). A nonsignificant reduction in survival to the higher concentrations of (R)-MDPV was accompanied by reduced reproductive output (at 1.00 and 1.79 μg L) and intrinsic rate of population increase (at 1.79 μg L). Our findings suggest that, in general, (S)-MDPV triggers more severe sub-chronic effects, whereas (R)-MDPV is associated with harmful effects for longer time exposure. |
| title | Enantioselective toxicity of 3,4-methylenedioxypyrovalerone in Daphnia magna: Assessment of morphophysiological, behavioural, biochemical and reproductive responses. |
| topic | Animals Daphnia Pyrrolidines Benzodioxoles Reproduction Stereoisomerism Water Pollutants, Chemical Behavior, Animal Synthetic Cathinone Dose-Response Relationship, Drug Daphnia magna |
| url | https://pubmed.ncbi.nlm.nih.gov/41115600/ |