Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Archives of gerontology and geriatrics
2026
|
| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41124892/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266136460591105 |
|---|---|
| author | Chang, Yun-Ching Liu, Hung-Wen Hsieh, Tsung-Jen Chang, Sue-Joan |
| author_facet | Chang, Yun-Ching Liu, Hung-Wen Hsieh, Tsung-Jen Chang, Sue-Joan Chang, Yun-Ching Liu, Hung-Wen Hsieh, Tsung-Jen Chang, Sue-Joan |
| collection | PubMed - marine biology |
| contents | The effects of Oligo-Fucoidan on muscle function in community-dwelling older adults: A double-blind, randomized, placebo-controlled trial. Chang, Yun-Ching Liu, Hung-Wen Hsieh, Tsung-Jen Chang, Sue-Joan Humans Double-Blind Method Male Aged Female Polysaccharides Dietary Supplements Muscle Strength Muscle, Skeletal Sarcopenia Middle Aged Independent Living Hand Strength Aged, 80 and over Physical Functional Performance Vitamin D Sarcopenia, characterized by age-related loss of muscle mass and function, presents a growing public health concern in aging populations. While resistance training remains the gold standard for management, alternative interventions are needed for individuals with limited exercise capacity. Fucoidan, a sulfated polysaccharide derived from brown seaweed, has demonstrated promising biological activities, including potential muscle-enhancing effects. This study investigated the effects of low-molecular-weight Oligo-Fucoidan supplementation on muscle strength, muscle mass, and physical performance in community-dwelling older adults. In this 12-week, randomized, double-blind, placebo-controlled trial, 60 participants aged ≥60 years were assigned to one of three groups: Oligo-Fucoidan, Oligo-Fucoidan with branched-chain amino acids (BCAA) and vitamin D, or placebo. Outcomes included handgrip strength, calf circumference, appendicular lean mass index (ALMI), five-times sit-to-stand (5STS), six-minute walk test (6MWT), and isokinetic knee extension (KE) strength. Oligo-Fucoidan supplementation significantly improved grip strength (p < 0.001; effect size r = 0.82), with 64.7 % of participants exceeding the minimal clinically important difference. Improvements in 6MWT distance (p < 0.001) were also observed, with 47.1 % of participants surpassing the minimal detectable change thresholds. No significant changes in muscle mass were noted, though the placebo group showed a reduction in calf circumference (p = 0.012). MANOVA of percent changes across six outcomes indicated significant overall group differences, driven primarily by greater improvements in grip strength in the Oligo-Fucoidan supplementation group compared with placebo. No adverse events were reported. Oligo-Fucoidan supplementation improved muscle strength and physical performance in older adults, suggesting its potential as a safe, non-pharmacological intervention for sarcopenia. Further research is warranted to evaluate long-term effects and optimize formulation. |
| format | Artículo científico |
| id | pubmed_41124892 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Archives of gerontology and geriatrics |
| record_format | pubmed |
| spellingShingle | The effects of Oligo-Fucoidan on muscle function in community-dwelling older adults: A double-blind, randomized, placebo-controlled trial. Chang, Yun-Ching Liu, Hung-Wen Hsieh, Tsung-Jen Chang, Sue-Joan Humans Double-Blind Method Male Aged Female Polysaccharides Dietary Supplements Muscle Strength Muscle, Skeletal Sarcopenia Middle Aged Independent Living Hand Strength Aged, 80 and over Physical Functional Performance Vitamin D The effects of Oligo-Fucoidan on muscle function in community-dwelling older adults: A double-blind, randomized, placebo-controlled trial. Chang, Yun-Ching Liu, Hung-Wen Hsieh, Tsung-Jen Chang, Sue-Joan Humans Double-Blind Method Male Aged Female Polysaccharides Dietary Supplements Muscle Strength Muscle, Skeletal Sarcopenia Middle Aged Independent Living Hand Strength Aged, 80 and over Physical Functional Performance Vitamin D Sarcopenia, characterized by age-related loss of muscle mass and function, presents a growing public health concern in aging populations. While resistance training remains the gold standard for management, alternative interventions are needed for individuals with limited exercise capacity. Fucoidan, a sulfated polysaccharide derived from brown seaweed, has demonstrated promising biological activities, including potential muscle-enhancing effects. This study investigated the effects of low-molecular-weight Oligo-Fucoidan supplementation on muscle strength, muscle mass, and physical performance in community-dwelling older adults. In this 12-week, randomized, double-blind, placebo-controlled trial, 60 participants aged ≥60 years were assigned to one of three groups: Oligo-Fucoidan, Oligo-Fucoidan with branched-chain amino acids (BCAA) and vitamin D, or placebo. Outcomes included handgrip strength, calf circumference, appendicular lean mass index (ALMI), five-times sit-to-stand (5STS), six-minute walk test (6MWT), and isokinetic knee extension (KE) strength. Oligo-Fucoidan supplementation significantly improved grip strength (p < 0.001; effect size r = 0.82), with 64.7 % of participants exceeding the minimal clinically important difference. Improvements in 6MWT distance (p < 0.001) were also observed, with 47.1 % of participants surpassing the minimal detectable change thresholds. No significant changes in muscle mass were noted, though the placebo group showed a reduction in calf circumference (p = 0.012). MANOVA of percent changes across six outcomes indicated significant overall group differences, driven primarily by greater improvements in grip strength in the Oligo-Fucoidan supplementation group compared with placebo. No adverse events were reported. Oligo-Fucoidan supplementation improved muscle strength and physical performance in older adults, suggesting its potential as a safe, non-pharmacological intervention for sarcopenia. Further research is warranted to evaluate long-term effects and optimize formulation. |
| title | The effects of Oligo-Fucoidan on muscle function in community-dwelling older adults: A double-blind, randomized, placebo-controlled trial. |
| topic | Humans Double-Blind Method Male Aged Female Polysaccharides Dietary Supplements Muscle Strength Muscle, Skeletal Sarcopenia Middle Aged Independent Living Hand Strength Aged, 80 and over Physical Functional Performance Vitamin D |
| url | https://pubmed.ncbi.nlm.nih.gov/41124892/ |