Phytochemical investigation, antimicrobial activities, and molecular docking studies on endemic (Aucher ex DC.) Zaika, Sukhor. & N.Kilian grown in Türkiye.
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| Autori principali: | , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
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Natural product research
2025
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| author | Bozdal, Gözde Korkmaz, Büşra Abanoz, Murat Emre Şahin, Büşra Uzuner, Ugur Bozdeveci, Arif Makbul, Serdar Yaylı, Nurettin |
| author_facet | Bozdal, Gözde Korkmaz, Büşra Abanoz, Murat Emre Şahin, Büşra Uzuner, Ugur Bozdeveci, Arif Makbul, Serdar Yaylı, Nurettin Bozdal, Gözde Korkmaz, Büşra Abanoz, Murat Emre Şahin, Büşra Uzuner, Ugur Bozdeveci, Arif Makbul, Serdar Yaylı, Nurettin |
| collection | PubMed - marine biology |
| contents | Phytochemical investigation, antimicrobial activities, and molecular docking studies on endemic (Aucher ex DC.) Zaika, Sukhor. & N.Kilian grown in Türkiye. Bozdal, Gözde Korkmaz, Büşra Abanoz, Murat Emre Şahin, Büşra Uzuner, Ugur Bozdeveci, Arif Makbul, Serdar Yaylı, Nurettin In this study, activity-guided isolation of the endemic (Aucher ex DC.) Zaika, Sukhor. & N.Kilian yielded five new compounds (8----glucopyranosyl-6-hydroxy-3-(4-hydroxyphenyl)-1-isochromen-1-one (), (3 ,3')-8,8'-oxy[6-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1-isochromen-1-one] (), 3--(4--glyceryl)---xylopyranosyl-5-methyl-4-pyran-4-one (), 2-carboxyl-3-hydroxy-4'-methoxy-5--(3--glyceryl)---xylopyranosylbibenzyl (), and 2-carboxyl-3,4'-dihydroxy-5--(--apiofuranosyl)-(1→6)--D-glucopyranosylbibenzyl (). Five known compounds as -coumaric acid (), scorzopigmecosite (), scorzocreticin (), quercetin (), and kelampayoside A (). Spectroscopic methods were used to characterise the structures of compounds . All the isolated compounds, except compound , exhibited an inhibition zone diameter of 10-12 mm against at least one of the nine different microorganisms tested. Compound was found to be the most effective with an MIC value of 12.5 μg/mL against . Additionally, molecular docking analysis of compounds was performed, targeting RhlR and DNA gyrase B enzymes. Among the identified compounds, compound 2 exhibited the most promising inhibitory activity against both targets, with binding energies of -12.0 and -11.3 kcal/mol, respectively. |
| format | Artículo científico |
| id | pubmed_41126564 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Natural product research |
| record_format | pubmed |
| spellingShingle | Phytochemical investigation, antimicrobial activities, and molecular docking studies on endemic (Aucher ex DC.) Zaika, Sukhor. & N.Kilian grown in Türkiye. Bozdal, Gözde Korkmaz, Büşra Abanoz, Murat Emre Şahin, Büşra Uzuner, Ugur Bozdeveci, Arif Makbul, Serdar Yaylı, Nurettin Phytochemical investigation, antimicrobial activities, and molecular docking studies on endemic (Aucher ex DC.) Zaika, Sukhor. & N.Kilian grown in Türkiye. Bozdal, Gözde Korkmaz, Büşra Abanoz, Murat Emre Şahin, Büşra Uzuner, Ugur Bozdeveci, Arif Makbul, Serdar Yaylı, Nurettin In this study, activity-guided isolation of the endemic (Aucher ex DC.) Zaika, Sukhor. & N.Kilian yielded five new compounds (8----glucopyranosyl-6-hydroxy-3-(4-hydroxyphenyl)-1-isochromen-1-one (), (3 ,3')-8,8'-oxy[6-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1-isochromen-1-one] (), 3--(4--glyceryl)---xylopyranosyl-5-methyl-4-pyran-4-one (), 2-carboxyl-3-hydroxy-4'-methoxy-5--(3--glyceryl)---xylopyranosylbibenzyl (), and 2-carboxyl-3,4'-dihydroxy-5--(--apiofuranosyl)-(1→6)--D-glucopyranosylbibenzyl (). Five known compounds as -coumaric acid (), scorzopigmecosite (), scorzocreticin (), quercetin (), and kelampayoside A (). Spectroscopic methods were used to characterise the structures of compounds . All the isolated compounds, except compound , exhibited an inhibition zone diameter of 10-12 mm against at least one of the nine different microorganisms tested. Compound was found to be the most effective with an MIC value of 12.5 μg/mL against . Additionally, molecular docking analysis of compounds was performed, targeting RhlR and DNA gyrase B enzymes. Among the identified compounds, compound 2 exhibited the most promising inhibitory activity against both targets, with binding energies of -12.0 and -11.3 kcal/mol, respectively. |
| title | Phytochemical investigation, antimicrobial activities, and molecular docking studies on endemic (Aucher ex DC.) Zaika, Sukhor. & N.Kilian grown in Türkiye. |
| url | https://pubmed.ncbi.nlm.nih.gov/41126564/ |