Dual roles of Makorin ring finger protein 1 in ubiquitination and RNA biology: regulatory mechanisms and therapeutic implications in human diseases.
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| Autori principali: | , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
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Biochemical pharmacology
2026
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| _version_ | 1868266136456396802 |
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| author | Wu, Jia-Le Wang, Zi-Xuan Chen, Jie Zhong, Hai-Jing Yang, Guan-Jun |
| author_facet | Wu, Jia-Le Wang, Zi-Xuan Chen, Jie Zhong, Hai-Jing Yang, Guan-Jun Wu, Jia-Le Wang, Zi-Xuan Chen, Jie Zhong, Hai-Jing Yang, Guan-Jun |
| collection | PubMed - marine biology |
| contents | Dual roles of Makorin ring finger protein 1 in ubiquitination and RNA biology: regulatory mechanisms and therapeutic implications in human diseases. Wu, Jia-Le Wang, Zi-Xuan Chen, Jie Zhong, Hai-Jing Yang, Guan-Jun Animals Humans Jumonji Domain-Containing Histone Demethylases Metabolic Diseases Metabolic Networks and Pathways Neoplasms Nerve Tissue Proteins Ribonucleoproteins Tuberculosis Tumor Suppressor Proteins Ubiquitin-Protein Ligases Ubiquitination RNA Ubiquitination dynamically regulates protein stability and signaling networks through post-translational modifications. Makorin ring finger protein 1 (MKRN1) is a unique member of the MKRN family that functions as E3 ubiquitin ligase and RNA-binding protein. It maintains cellular homeostasis via a dual regulatory mechanism involving ubiquitination and RNA biology. This review summarizes the regulatory mechanisms of MKRN1 in core pathways, such as p53-p21, Wnt/β-catenin, transforming growth factor beta, phosphatidylinositol 3 kinase/protein kinase, nuclear factor kappa B, and various pathological states, including metabolic disorders, tuberculosis, and cancer. We critically evaluated its structural architecture, disease-related functions, and pharmacological potential of MKRN1. We highlight that therapeutic targeting strategies, such as indirect inhibitors of KDM7A, discuss challenges in the development of direct MKRN1-targeting drugs, and propose that elucidating the interaction between MKRN1 in the ubiquitin-proteasome system and RNA regulatory system may open new avenues for the treatment of human diseases. Overall, MKRN1 exhibits complex, context-dependent roles across various diseases, making it a challenging yet compelling therapeutic target. |
| format | Artículo científico |
| id | pubmed_41130303 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Biochemical pharmacology |
| record_format | pubmed |
| spellingShingle | Dual roles of Makorin ring finger protein 1 in ubiquitination and RNA biology: regulatory mechanisms and therapeutic implications in human diseases. Wu, Jia-Le Wang, Zi-Xuan Chen, Jie Zhong, Hai-Jing Yang, Guan-Jun Animals Humans Jumonji Domain-Containing Histone Demethylases Metabolic Diseases Metabolic Networks and Pathways Neoplasms Nerve Tissue Proteins Ribonucleoproteins Tuberculosis Tumor Suppressor Proteins Ubiquitin-Protein Ligases Ubiquitination RNA Dual roles of Makorin ring finger protein 1 in ubiquitination and RNA biology: regulatory mechanisms and therapeutic implications in human diseases. Wu, Jia-Le Wang, Zi-Xuan Chen, Jie Zhong, Hai-Jing Yang, Guan-Jun Animals Humans Jumonji Domain-Containing Histone Demethylases Metabolic Diseases Metabolic Networks and Pathways Neoplasms Nerve Tissue Proteins Ribonucleoproteins Tuberculosis Tumor Suppressor Proteins Ubiquitin-Protein Ligases Ubiquitination RNA Ubiquitination dynamically regulates protein stability and signaling networks through post-translational modifications. Makorin ring finger protein 1 (MKRN1) is a unique member of the MKRN family that functions as E3 ubiquitin ligase and RNA-binding protein. It maintains cellular homeostasis via a dual regulatory mechanism involving ubiquitination and RNA biology. This review summarizes the regulatory mechanisms of MKRN1 in core pathways, such as p53-p21, Wnt/β-catenin, transforming growth factor beta, phosphatidylinositol 3 kinase/protein kinase, nuclear factor kappa B, and various pathological states, including metabolic disorders, tuberculosis, and cancer. We critically evaluated its structural architecture, disease-related functions, and pharmacological potential of MKRN1. We highlight that therapeutic targeting strategies, such as indirect inhibitors of KDM7A, discuss challenges in the development of direct MKRN1-targeting drugs, and propose that elucidating the interaction between MKRN1 in the ubiquitin-proteasome system and RNA regulatory system may open new avenues for the treatment of human diseases. Overall, MKRN1 exhibits complex, context-dependent roles across various diseases, making it a challenging yet compelling therapeutic target. |
| title | Dual roles of Makorin ring finger protein 1 in ubiquitination and RNA biology: regulatory mechanisms and therapeutic implications in human diseases. |
| topic | Animals Humans Jumonji Domain-Containing Histone Demethylases Metabolic Diseases Metabolic Networks and Pathways Neoplasms Nerve Tissue Proteins Ribonucleoproteins Tuberculosis Tumor Suppressor Proteins Ubiquitin-Protein Ligases Ubiquitination RNA |
| url | https://pubmed.ncbi.nlm.nih.gov/41130303/ |