The Efficacy of Hesperidin in the Reduction of Atherosclerosis in ApoE Mice and Its Possible Mechanism of Action.
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| Format: | Artículo científico |
| Sprache: | en |
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Foods (Basel, Switzerland)
2025
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| _version_ | 1868266136432279552 |
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| author | Wang, Qi Huang, Xiaoxia Zhang, Mengyao Sang, Shangyuan Fang, Linrong Zhang, Ruilin Xia, Silei Liu, Yanan |
| author_facet | Wang, Qi Huang, Xiaoxia Zhang, Mengyao Sang, Shangyuan Fang, Linrong Zhang, Ruilin Xia, Silei Liu, Yanan Wang, Qi Huang, Xiaoxia Zhang, Mengyao Sang, Shangyuan Fang, Linrong Zhang, Ruilin Xia, Silei Liu, Yanan |
| collection | PubMed - marine biology |
| contents | The Efficacy of Hesperidin in the Reduction of Atherosclerosis in ApoE Mice and Its Possible Mechanism of Action. Wang, Qi Huang, Xiaoxia Zhang, Mengyao Sang, Shangyuan Fang, Linrong Zhang, Ruilin Xia, Silei Liu, Yanan Atherosclerosis (AS) currently lacks fully effective treatments. This study investigated the natural compound hesperidin as a potential therapy. Apolipoprotein E knockout (ApoE) mice were used as a model of atherosclerosis; we found that hesperidin treatment improved physiological and metabolic health, reduced plaque formation, and decreased systemic inflammation and oxidative stress. Hesperidin also reshaped gut microbiota, increasing beneficial bacteria ( and ) and significantly lowering fecal levels of branched-chain amino acids (BCAAs: valine, leucine, and isoleucine) by 27.4%, 50.1%, and 40.8%, respectively. These changes were linked to specific microbial shifts. We conclude that hesperidin alleviates atherosclerosis likely by modulating the gut microbiota-BCAA-host axis, identifying it as a promising dietary intervention or therapeutic agent. |
| format | Artículo científico |
| id | pubmed_41154096 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Foods (Basel, Switzerland) |
| record_format | pubmed |
| spellingShingle | The Efficacy of Hesperidin in the Reduction of Atherosclerosis in ApoE Mice and Its Possible Mechanism of Action. Wang, Qi Huang, Xiaoxia Zhang, Mengyao Sang, Shangyuan Fang, Linrong Zhang, Ruilin Xia, Silei Liu, Yanan The Efficacy of Hesperidin in the Reduction of Atherosclerosis in ApoE Mice and Its Possible Mechanism of Action. Wang, Qi Huang, Xiaoxia Zhang, Mengyao Sang, Shangyuan Fang, Linrong Zhang, Ruilin Xia, Silei Liu, Yanan Atherosclerosis (AS) currently lacks fully effective treatments. This study investigated the natural compound hesperidin as a potential therapy. Apolipoprotein E knockout (ApoE) mice were used as a model of atherosclerosis; we found that hesperidin treatment improved physiological and metabolic health, reduced plaque formation, and decreased systemic inflammation and oxidative stress. Hesperidin also reshaped gut microbiota, increasing beneficial bacteria ( and ) and significantly lowering fecal levels of branched-chain amino acids (BCAAs: valine, leucine, and isoleucine) by 27.4%, 50.1%, and 40.8%, respectively. These changes were linked to specific microbial shifts. We conclude that hesperidin alleviates atherosclerosis likely by modulating the gut microbiota-BCAA-host axis, identifying it as a promising dietary intervention or therapeutic agent. |
| title | The Efficacy of Hesperidin in the Reduction of Atherosclerosis in ApoE Mice and Its Possible Mechanism of Action. |
| url | https://pubmed.ncbi.nlm.nih.gov/41154096/ |