Microbial dysbiosis and hepatic inflammation under combined pesticide exposure: Insights into gut-liver axis disruption in Japanese medaka.
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Journal of hazardous materials
2025
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| _version_ | 1868266132960444417 |
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| author | Jawad, Muhammad Xu, Haijing Nasir, Sana Yin, Jie Wu, Can Wang, Aimin Hong, Ni Li, Mingyou |
| author_facet | Jawad, Muhammad Xu, Haijing Nasir, Sana Yin, Jie Wu, Can Wang, Aimin Hong, Ni Li, Mingyou Jawad, Muhammad Xu, Haijing Nasir, Sana Yin, Jie Wu, Can Wang, Aimin Hong, Ni Li, Mingyou |
| collection | PubMed - marine biology |
| contents | Microbial dysbiosis and hepatic inflammation under combined pesticide exposure: Insights into gut-liver axis disruption in Japanese medaka. Jawad, Muhammad Xu, Haijing Nasir, Sana Yin, Jie Wu, Can Wang, Aimin Hong, Ni Li, Mingyou Animals Gastrointestinal Microbiome Liver Pyrethrins Oryzias Dysbiosis Water Pollutants, Chemical Triazoles Nitriles Pesticides Inflammation Environmental pesticides such as fenvalerate (FEN) and tebuconazole (TEB) frequently co-occur in aquatic ecosystems, yet their combined impacts on gut-liver immune communication remain poorly understood. This study evaluated the chronic toxicity of FEN (0.029 mg/L), TEB (1 mg/L), and their mixture (0.01 mg/L FEN + 0.5 mg/L TEB) in adult Japanese medaka (Oryzias latipes) through an integrative approach encompassing histopathology, biochemical assays, gut microbiota profiling, and hepatic transcriptomics. Co-exposure induced significant (p |
| format | Artículo científico |
| id | pubmed_41161167 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of hazardous materials |
| record_format | pubmed |
| spellingShingle | Microbial dysbiosis and hepatic inflammation under combined pesticide exposure: Insights into gut-liver axis disruption in Japanese medaka. Jawad, Muhammad Xu, Haijing Nasir, Sana Yin, Jie Wu, Can Wang, Aimin Hong, Ni Li, Mingyou Animals Gastrointestinal Microbiome Liver Pyrethrins Oryzias Dysbiosis Water Pollutants, Chemical Triazoles Nitriles Pesticides Inflammation Microbial dysbiosis and hepatic inflammation under combined pesticide exposure: Insights into gut-liver axis disruption in Japanese medaka. Jawad, Muhammad Xu, Haijing Nasir, Sana Yin, Jie Wu, Can Wang, Aimin Hong, Ni Li, Mingyou Animals Gastrointestinal Microbiome Liver Pyrethrins Oryzias Dysbiosis Water Pollutants, Chemical Triazoles Nitriles Pesticides Inflammation Environmental pesticides such as fenvalerate (FEN) and tebuconazole (TEB) frequently co-occur in aquatic ecosystems, yet their combined impacts on gut-liver immune communication remain poorly understood. This study evaluated the chronic toxicity of FEN (0.029 mg/L), TEB (1 mg/L), and their mixture (0.01 mg/L FEN + 0.5 mg/L TEB) in adult Japanese medaka (Oryzias latipes) through an integrative approach encompassing histopathology, biochemical assays, gut microbiota profiling, and hepatic transcriptomics. Co-exposure induced significant (p |
| title | Microbial dysbiosis and hepatic inflammation under combined pesticide exposure: Insights into gut-liver axis disruption in Japanese medaka. |
| topic | Animals Gastrointestinal Microbiome Liver Pyrethrins Oryzias Dysbiosis Water Pollutants, Chemical Triazoles Nitriles Pesticides Inflammation |
| url | https://pubmed.ncbi.nlm.nih.gov/41161167/ |