Investigation of N-desmethyl-acetamiprid-induced neurotransmitter disturbances in cerebrospinal fluid from leukemia patients.
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
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Environmental toxicology and pharmacology
2025
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| _version_ | 1868266132942618626 |
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| author | Si, Mengya Khan, Muhammad Nadeem Bilal, Hazrat Shafiq, Muhammad Khan, Sabir Guo, Xiaoling Wang, Meimei Wu, Jilong Zhen, Wang Yao, Fen Li, Adela Jing Jiao, Xiaoyang |
| author_facet | Si, Mengya Khan, Muhammad Nadeem Bilal, Hazrat Shafiq, Muhammad Khan, Sabir Guo, Xiaoling Wang, Meimei Wu, Jilong Zhen, Wang Yao, Fen Li, Adela Jing Jiao, Xiaoyang Si, Mengya Khan, Muhammad Nadeem Bilal, Hazrat Shafiq, Muhammad Khan, Sabir Guo, Xiaoling Wang, Meimei Wu, Jilong Zhen, Wang Yao, Fen Li, Adela Jing Jiao, Xiaoyang |
| collection | PubMed - marine biology |
| contents | Investigation of N-desmethyl-acetamiprid-induced neurotransmitter disturbances in cerebrospinal fluid from leukemia patients. Si, Mengya Khan, Muhammad Nadeem Bilal, Hazrat Shafiq, Muhammad Khan, Sabir Guo, Xiaoling Wang, Meimei Wu, Jilong Zhen, Wang Yao, Fen Li, Adela Jing Jiao, Xiaoyang Humans Male Female Adult Middle Aged Neurotransmitter Agents Aged Child Leukemia Adolescent Young Adult Child, Preschool Biomarkers Neonicotinoids (NEOs) and their metabolites impact neuronal function; however, their effects on neurotransmitters remain unexplored. We analyzed cerebrospinal fluid (CSF) from leukemia patients with differing concentrations of N-desmethyl-acetamiprid (N-dm-ACE) for neurotransmitter profiling. Neurotransmitters and biomarkers were measured in CSF, blood, and serum from 39 patients (19 low and 20 high N-dm-ACE) across three age groups: children, adults, and elders. Significant differences (p ≤ 0.05) in neurotransmitters were found among groups, including glutamic acid (253.45 ± 388.16 & 101.11 ± 52.79), aspartic acid (79.64 ± 87.46 & 0.00), tryptophan (325.89 ± 76.47 & 508.09 ± 331.35), and tyrosine (984.41 ± 348.78 ng/mL). Regression analysis indicated that N-dm-ACE is significantly (p |
| format | Artículo científico |
| id | pubmed_41173078 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Environmental toxicology and pharmacology |
| record_format | pubmed |
| spellingShingle | Investigation of N-desmethyl-acetamiprid-induced neurotransmitter disturbances in cerebrospinal fluid from leukemia patients. Si, Mengya Khan, Muhammad Nadeem Bilal, Hazrat Shafiq, Muhammad Khan, Sabir Guo, Xiaoling Wang, Meimei Wu, Jilong Zhen, Wang Yao, Fen Li, Adela Jing Jiao, Xiaoyang Humans Male Female Adult Middle Aged Neurotransmitter Agents Aged Child Leukemia Adolescent Young Adult Child, Preschool Biomarkers Investigation of N-desmethyl-acetamiprid-induced neurotransmitter disturbances in cerebrospinal fluid from leukemia patients. Si, Mengya Khan, Muhammad Nadeem Bilal, Hazrat Shafiq, Muhammad Khan, Sabir Guo, Xiaoling Wang, Meimei Wu, Jilong Zhen, Wang Yao, Fen Li, Adela Jing Jiao, Xiaoyang Humans Male Female Adult Middle Aged Neurotransmitter Agents Aged Child Leukemia Adolescent Young Adult Child, Preschool Biomarkers Neonicotinoids (NEOs) and their metabolites impact neuronal function; however, their effects on neurotransmitters remain unexplored. We analyzed cerebrospinal fluid (CSF) from leukemia patients with differing concentrations of N-desmethyl-acetamiprid (N-dm-ACE) for neurotransmitter profiling. Neurotransmitters and biomarkers were measured in CSF, blood, and serum from 39 patients (19 low and 20 high N-dm-ACE) across three age groups: children, adults, and elders. Significant differences (p ≤ 0.05) in neurotransmitters were found among groups, including glutamic acid (253.45 ± 388.16 & 101.11 ± 52.79), aspartic acid (79.64 ± 87.46 & 0.00), tryptophan (325.89 ± 76.47 & 508.09 ± 331.35), and tyrosine (984.41 ± 348.78 ng/mL). Regression analysis indicated that N-dm-ACE is significantly (p |
| title | Investigation of N-desmethyl-acetamiprid-induced neurotransmitter disturbances in cerebrospinal fluid from leukemia patients. |
| topic | Humans Male Female Adult Middle Aged Neurotransmitter Agents Aged Child Leukemia Adolescent Young Adult Child, Preschool Biomarkers |
| url | https://pubmed.ncbi.nlm.nih.gov/41173078/ |