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| Main Authors: | , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Aquaculture nutrition
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41180372/ |
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Table of Contents:
- Dietary Supplementation With Extract Modulates Microbial Metabolic Functions, Improving Growth Performance, Innate Immunity, and Antioxidant Capacity in Juvenile (GIRARD, 1852). Cai, Minglang Zhou, Weiqing Zhou, Xixun Wang, Aimin Zhang, Junzhi Hu, Yi Concerns regarding food-borne interventions in crayfish have been raised due to excessive farming densities and the overuse of drugs in aquaculture. This research focused on examining the dose-response relationship of extract supplementation on growth performance, hepatopancreas antioxidant status, and innate immune function in crayfish, while exploring the microbiota-mediated metabolic pathways involved. A total of 750 juvenile crayfish (4.00 g) were randomly assigned to five treatments and fed diets supplemented with extract at concentrations of 0, 500, 1000, 1500, and 2000 mg/kg for 42 days. The results demonstrated that dietary extract improved the growth and hepatic health status, as indicated by well-structured hepatic tubules and increased fibroblast cells, as well as lower hemolymph glutamic oxaloacetic transaminase (GOT) level ( < 0.05). Dietary supplementation with 1500 mg/kg extracts significantly increased hemolymph lysozyme (LZM) and acid phosphatase (ACP) activities ( < 0.05). Additionally, extract supplementation considerably increased hepatopancreas glutathione (GSH) content and activities of catalase (CAT), superoxide dismutase (SOD), and GSH reductase (GR) ( < 0.05). Furthermore, dietary extract alleviated microbial dysbiosis, as characterized by the observed decrease in opportunistic pathogens and and an increase in beneficial taxa . Further findings found that 349 differential microbes were identified, with , , and playing key roles. In summary, the optimal dietary inclusion level of extract was recommended to be 1507.89-1614.26 mg/kg. Dietary supplementation with 1500 mg/kg of extract improved the immunity and antioxidant capacities of crayfish by reshaping microbial co-occurrence networks.