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| Format: | Artículo científico |
| Language: | en |
| Published: |
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41197930/ |
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| _version_ | 1868266130297061377 |
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| author | Cunha, Marta Lenzi, Alessio Figueiredo, Constança De Marchi, Lucia Leite, Carla Russo, Tania Monni, Gianfranca Meucci, Valentina Soares, Amadeu M V M Polese, Gianluca Pereira, Eduarda Pretti, Carlo Freitas, Rosa |
| author_facet | Cunha, Marta Lenzi, Alessio Figueiredo, Constança De Marchi, Lucia Leite, Carla Russo, Tania Monni, Gianfranca Meucci, Valentina Soares, Amadeu M V M Polese, Gianluca Pereira, Eduarda Pretti, Carlo Freitas, Rosa Cunha, Marta Lenzi, Alessio Figueiredo, Constança De Marchi, Lucia Leite, Carla Russo, Tania Monni, Gianfranca Meucci, Valentina Soares, Amadeu M V M Polese, Gianluca Pereira, Eduarda Pretti, Carlo Freitas, Rosa |
| collection | PubMed - marine biology |
| contents | From metabolites to tissues: A comprehensive analysis of salinity-driven modulation of tetracycline effects in Mytilus galloprovincialis. Cunha, Marta Lenzi, Alessio Figueiredo, Constança De Marchi, Lucia Leite, Carla Russo, Tania Monni, Gianfranca Meucci, Valentina Soares, Amadeu M V M Polese, Gianluca Pereira, Eduarda Pretti, Carlo Freitas, Rosa Animals Mytilus Tetracycline Salinity Water Pollutants, Chemical Oxidative Stress Anti-Bacterial Agents Metabolomics Energy Metabolism Environmental salinity shifts, intensified by climate change, can influence the toxicity of pollutants such as antibiotics in marine organisms. In this study, specimens of the mussel Mytilus galloprovincialis were exposed for 28 days to three salinity levels (20, 30, and 40) in the presence or absence of tetracycline (TC) (1 mg/L). At the end of the exposure period, the effects were evaluated using an integrated metabolomic, biochemical, and histopathological approach. Tetracycline bioaccumulation did not differ significantly across salinities, indicating that biological effects were driven by stressor interactions rather than uptake. Metabolomic profiling showed that salinity and salinity-TC combinations had stronger impacts than TC alone. At salinity 20, mussels exhibited early oxidative stress and metabolic adjustments, along with tissue atrophy and lipofuscin buildup. Mussels at salinity 30 displayed relative physiological stability despite moderate histological changes under TC. In contrast, salinity 40 caused severe cellular damage, including membrane remodeling, lipid peroxidation, depleted antioxidants, and neurotoxic responses. The integrated multi-level analysis revealed coordinated stress responses involving oxidative stress, altered energy metabolism, and detoxification. Overall, these findings highlight salinity 30 as the optimal condition for M. galloprovincialis and emphasize the synergistic effects of climate-driven salinity changes and antibiotic pollution, underscoring the need to account for abiotic stressors in ecotoxicological assessments. |
| format | Artículo científico |
| id | pubmed_41197930 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP |
| record_format | pubmed |
| spellingShingle | From metabolites to tissues: A comprehensive analysis of salinity-driven modulation of tetracycline effects in Mytilus galloprovincialis. Cunha, Marta Lenzi, Alessio Figueiredo, Constança De Marchi, Lucia Leite, Carla Russo, Tania Monni, Gianfranca Meucci, Valentina Soares, Amadeu M V M Polese, Gianluca Pereira, Eduarda Pretti, Carlo Freitas, Rosa Animals Mytilus Tetracycline Salinity Water Pollutants, Chemical Oxidative Stress Anti-Bacterial Agents Metabolomics Energy Metabolism From metabolites to tissues: A comprehensive analysis of salinity-driven modulation of tetracycline effects in Mytilus galloprovincialis. Cunha, Marta Lenzi, Alessio Figueiredo, Constança De Marchi, Lucia Leite, Carla Russo, Tania Monni, Gianfranca Meucci, Valentina Soares, Amadeu M V M Polese, Gianluca Pereira, Eduarda Pretti, Carlo Freitas, Rosa Animals Mytilus Tetracycline Salinity Water Pollutants, Chemical Oxidative Stress Anti-Bacterial Agents Metabolomics Energy Metabolism Environmental salinity shifts, intensified by climate change, can influence the toxicity of pollutants such as antibiotics in marine organisms. In this study, specimens of the mussel Mytilus galloprovincialis were exposed for 28 days to three salinity levels (20, 30, and 40) in the presence or absence of tetracycline (TC) (1 mg/L). At the end of the exposure period, the effects were evaluated using an integrated metabolomic, biochemical, and histopathological approach. Tetracycline bioaccumulation did not differ significantly across salinities, indicating that biological effects were driven by stressor interactions rather than uptake. Metabolomic profiling showed that salinity and salinity-TC combinations had stronger impacts than TC alone. At salinity 20, mussels exhibited early oxidative stress and metabolic adjustments, along with tissue atrophy and lipofuscin buildup. Mussels at salinity 30 displayed relative physiological stability despite moderate histological changes under TC. In contrast, salinity 40 caused severe cellular damage, including membrane remodeling, lipid peroxidation, depleted antioxidants, and neurotoxic responses. The integrated multi-level analysis revealed coordinated stress responses involving oxidative stress, altered energy metabolism, and detoxification. Overall, these findings highlight salinity 30 as the optimal condition for M. galloprovincialis and emphasize the synergistic effects of climate-driven salinity changes and antibiotic pollution, underscoring the need to account for abiotic stressors in ecotoxicological assessments. |
| title | From metabolites to tissues: A comprehensive analysis of salinity-driven modulation of tetracycline effects in Mytilus galloprovincialis. |
| topic | Animals Mytilus Tetracycline Salinity Water Pollutants, Chemical Oxidative Stress Anti-Bacterial Agents Metabolomics Energy Metabolism |
| url | https://pubmed.ncbi.nlm.nih.gov/41197930/ |